PKM2 (Tyr105) Antibody

• Catalog number
  bs-3334R
• Price
  Please ask
• Size
  0.1ml

• Long name
  PKM2 (Tyr105) Primary Polyclonal Antibody
• Also known as
  PKM2 (Tyr105) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  PKM2 Tyr105
• Specificity
  This is a highly specific antibody against PKM2 Tyr105.
• Modification s
  Phosphorylation
• Modification site s
  Tyr105
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  97-121/531
• Subcellular location
  Cytoplasm, Nucleus
• Source
  KLH conjugated synthetic phosphopeptide derived from human PKM2 around the phosphorylation site of Tyr105
• Gene ID number
  5315
• Swiss Prot
  P14618
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Pyruvate kinase PKM; Cytosolic thyroid hormone-binding protein; CTHBP; Opa-interacting protein 3; OIP-3; Pyruvate kinase 2/3; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; THBP1; Tumor M2-PK; p58; PKM; OIP3; PK2; PK3; PKM2
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PKM2   Tyr105  
• Gene symbol
  PKM
• Short name
  Anti-PKM2 Tyr105
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  PKM2 (Tyr105) Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  pyruvate kinase, muscle, CTHBP and HEL-S-30 and OIP3 and PK3 and PKM2 and TCB and THBP1, PKM2 and IDBG-20117 and ENSG00000067225 and 5315, poly(A) RNA binding, nuclei, Pkm and IDBG-173276 and ENSMUSG00000032294 and 18746, PKM2 and IDBG-645572 and ENSBTAG00000001601 and 512571

Gene info

• Identity
  HGNC:9021
• Gene
  PKM
• Long gene name
  pyruvate kinase M1/2
• Synonyms gene
  • PKM2
• Synonyms gene name
  • pyruvate kinase, muscle
• Synonyms
  • THBP1
  • OIP3
  • PK3
• GenBank acession
  • M23725
• Locus
  15q23
• Discovery year
  2001-06-22
• Entrez gene record
  5315
• Pubmed identfication
  • 2040271
• VEGA ID
  OTTHUMG00000172709

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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