PKC beta Antibody

• Catalog number
  F50027-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  PKC beta
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC, ELISA
• Recommended dilutions
  Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
• Notes
  Titration of the PKC beta antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This PKC beta antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P05771
• Purity
  Purified
• Description
  Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKC beta is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Isoform 1 uses an alternate exon at the 3' end compared to isoform 2, which includes a part of the coding region. The resulting isoform 1 has a distinct and shorter C-terminus, as compared to isoform 2.
• Immunogen
  A portion of amino acids 303-334 from the human protein was used as the immunogen for this PKC beta antibody.
• Storage
  Aliquot the PKC beta antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PKC   beta  
• Gene symbol
  PRKCH, PRKD1, PRRT2, PRKDC
• Short name
  Anti-PKC beta
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to PKC beta
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9403
• Gene
  PRKCH
• Long gene name
  protein kinase C eta
• Synonyms gene
  • PRKCL
• Synonyms gene name
  • protein kinase C, eta
• Synonyms
  • PKC-L
  • PKCL
• GenBank acession
  • M55284
• Locus
  14q23.1
• Discovery year
  1992-06-26
• Entrez gene record
  5583
• Pubmed identfication
  • 1986216
  • 1545821
• RefSeq identity
  • NM_006255
• Classification
  • C2 domain containing protein kinases
  • AGC family kinases
• VEGA ID
  OTTHUMG00000152341

Gene info

• Identity
  HGNC:9407
• Gene
  PRKD1
• Long gene name
  protein kinase D1
• Synonyms gene
  • PRKCM
• Synonyms gene name
  • protein kinase C, mu
• Synonyms
  • PKCM
  • PKD
  • PKC-mu
• Locus
  14q12
• Discovery year
  1994-05-16
• Entrez gene record
  5587
• Pubmed identfication
  • 8119958
  • 10965134
• RefSeq identity
  • NM_002742
• Classification
  • Pleckstrin homology domain containing
• VEGA ID
  OTTHUMG00000140203

Gene info

• Identity
  HGNC:30500
• Gene
  PRRT2
• Long gene name
  proline rich transmembrane protein 2
• Synonyms gene
  • ICCA
  • DYT10
• Synonyms gene name
  • infantile convulsions and paroxysmal choreoathetosis
  • dystonia 10
  • proline-rich transmembrane protein 2
• Synonyms
  • FLJ25513
  • DKFZp547J199
  • IFITMD1
  • FICCA
  • DSPB3
  • PKC
  • EKD1
• Synonyms name
  • interferon induced transmembrane protein domain containing 1
  • dispanin subfamily B member 3
• GenBank acession
  • BC011405
• Locus
  16p11.2
• Discovery year
  2005-11-25
• Entrez gene record
  112476
• Pubmed identfication
  • 22101681
  • 22243967
  • 29346777
• RefSeq identity
  • NM_145239
• Classification
  • interferon induced transmembrane protein domain containing
• VEGA ID
  OTTHUMG00000177142

Gene info

• Identity
  HGNC:9413
• Gene
  PRKDC
• Long gene name
  protein kinase, DNA-activated, catalytic subunit
• Synonyms gene
  • HYRC
  • HYRC1
• Synonyms gene name
  • protein kinase, DNA-activated, catalytic polypeptide
• Synonyms
  • DNPK1
  • p350
  • DNAPK
  • XRCC7
  • DNA-PKcs
  • DNAPKc
  • DNA-PKC
  • p460
• Synonyms name
  • DNA-dependent protein kinase catalytic subunit
• Locus
  8q11.21
• Discovery year
  1993-11-09
• Entrez gene record
  5591
• Pubmed identfication
  • 7638222
• RefSeq identity
  • NM_001081640
• Classification
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000164239
• Locus Specific Databases
  • LRG_162

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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