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Alternative_name
3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone; NSC 407292; RJC 02792
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Description
Phloretin is a natural phenol which inhibits a variety of transporters. It inhibits the monocarboxylate transporters MCT1 and MCT2 (IC₅₀ = 28 and 14 µM, respectively), restricting the rapid transport of monocarboxylates like lactate and pyruvate across the plasma membrane. Phloretin also blocks the sodium/D-glucose cotransporter (Ki = 86 µM) and the human concentrative nucleoside transporter 3 (Ki = 32 µM). Blocks L-type Ca²⁺ channels; activates Ca²⁺-activated K⁺ channels in amphibian myelinated nerve fibers.
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CAS Number
60-82-2
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₁₅H₁₄O₅
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Molecular Weight
274.27
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (>25 mg/ml)
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Handling
Protect from air and light
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Tag Line
A natural phenol which inhibits a variety of transporters
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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MDL Number
MFCD00002288
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PubChem CID
4788
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SMILES
C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O
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InChi
InChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
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InChi Key
VGEREEWJJVICBM-UHFFFAOYSA-N
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MSDS Available
Yes