PAR4 (Thr163) Antibody

• Catalog number
  bs-3325R
• Price
  Please ask
• Size
  0.1ml

• Long name
  PAR4 (Thr163) Primary Polyclonal Antibody
• Also known as
  PAR4 (Thr163) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  PAR4 Thr163
• Specificity
  This is a highly specific antibody against PAR4 Thr163.
• Modification s
  Phosphorylation
• Modification site s
  Thr163
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human PAR4 around the phosphorylation site of Thr163
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  PAR4 is a member of a unique family of GPCRs, the proteinase-activated receptors (PARs), that are activated by proteolytic cleavage of the N-terminal domain of the receptor to reveal a tethered ligand. The PAR family consists of 4 receptors; PAR1 and PAR3 are activated by thrombin, and PAR2 and PAR4 are activated by several serine proteases (Macfarlane et al., 2001). PAR4 is expressed along with PAR1 on human platelets, and each plays an important role in thrombin-induced platelet aggregation (Holinstat et al., 2006). However, platelets from mice express PAR4 but not PAR1, and platelets from mice lacking PAR4 fail to aggregate in response to thrombin (Sambrano et al., 2001). Mice lacking PAR4 are protected from mesenteric arteriole thrombosis, indicating that PAR4 is a potential target for treatment of thrombosis in humans.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  PAR 4; Par4 induced by effectors of apoptosis; PAWR; PRKC Apoptosis WT1 Regulator; PRKC apoptosis WT1 regulator protein; Prostate apoptosis response 4 protein; Prostate apoptosis response protein 4; Prostate apoptosis response protein PAR 4; Proteinase-Activated Receptor 4; Transcriptional repressor Par-4-like protein PAWR; TRANSCRIPTIONAL REPRESSOR PAR4; WT1 Interacting Protein; protease-activated receptor 4; 2310001G03Rik.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PAR4   Thr163  
• Gene symbol
  F2RL3, PWAR4, PAWR
• Short name
  Anti-PAR4 Thr163
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  PAR4 (Thr163) Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3540
• Gene
  F2RL3
• Long gene name
  F2R like thrombin or trypsin receptor 3
• Synonyms gene name
  • coagulation factor II (thrombin) receptor-like 3
  • F2R like thrombin/trypsin receptor 3
• Synonyms
  • PAR4
• Synonyms name
  • proteinase-activated receptor-4
• GenBank acession
  • AF055917
• Locus
  19p13.11
• Discovery year
  1999-01-13
• Entrez gene record
  9002
• Pubmed identfication
  • 9618465
• RefSeq identity
  • NM_003950
• Classification
  • F2R receptors
• VEGA ID
  OTTHUMG00000182647
• Locus Specific Databases
  • LRG_633

Gene info

• Identity
  HGNC:29998
• Gene
  PWAR4
• Long gene name
  Prader Willi/Angelman region RNA 4
• Synonyms
  • PAR4
  • PAR-4
• Locus
  15q11.2
• Discovery year
  2013-06-14
• Entrez gene record
  347745
• Pubmed identfication
  • 11106375
  • 7987392
• Classification
  • Long non-coding RNAs with non-systematic symbols

Gene info

• Identity
  HGNC:8614
• Gene
  PAWR
• Long gene name
  pro-apoptotic WT1 regulator
• Synonyms gene name
  • PRKC, apoptosis, WT1, regulator
• Synonyms
  • par-4
  • PAR4
• Synonyms name
  • prostate apoptosis response-4
• GenBank acession
  • U63809
• Locus
  12q21.2
• Discovery year
  1998-06-05
• Entrez gene record
  5074
• Pubmed identfication
  • 8943350
  • 9790775
• RefSeq identity
  • NM_002583
• VEGA ID
  OTTHUMG00000170080

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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