PAK4 Polyclonal Antibody
-
Catalog numberCAC07276
-
PricePlease ask
-
Size50 μg
-
-
Other namep21-activated kinase 4,PAK-4,PAK4,KIAA1142
-
ImmunogenRecombinant human Serine/threonine-protein kinase PAK 4 protein (1-426AA)
-
Verified reactivityHuman
-
Verified applicationsELISA,IHC. Recommended dilution:IHC:1:20-1:200
-
Raised inRabbit
-
ClonalityPolyclonal
-
Protein numberO96013
-
Gene numberPlease refer to GenBank
-
NCBI numberPlease refer to NCBI
-
PurityCaprylic Acid Ammonium Sulfate Precipitation Purified
-
Storage recommendationAliquot and store at -20°C. Minimize freezing and thawing.
-
Use before1 year
-
Shipping requirementsBlue ice
-
Estimated production time3-7 business days
-
Supplementary informationSerine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.
-
NotesFor research use only. Not for diagnostic procedures.
-
PropertiesIf you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
GroupPolyclonals and antibodies
-
AboutPolyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
-
French translationanticorps
-
Gene target
-
Gene symbolPAK4
-
Short namePAK4 Polyclonal Antibody
-
TechniquePolyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
-
LabelUnconjugated
-
Alternative namePAK4 polyclonal (antibody to-)
-
Alternative techniquepolyclonals, antibodies
-
Gene info
-
Identity
-
Gene
-
Long gene namep21 (RAC1) activated kinase 4
-
Synonyms gene name
- p21(CDKN1A)-activated kinase 4
- p21 protein (Cdc42/Rac)-activated kinase 4
-
GenBank acession
-
Locus
-
Discovery year2001-07-12
-
Entrez gene record
-
Pubmed identfication
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data