PAC-1 monoclonal antibody

• Catalog number
  1F-145-T100
• Price
  Please ask
• Size
  100 assays

• Long name
  Mouse Monoclonal Antibody against Human PAC-1, Clone: PAC-1
• Antigen
  PAC-1
• Species reactivity
  Human (Homo sapiens)
• Negative species reactivity
  at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  PAC-1
• Applications
  FC, IP, ICC
• Immunogen
  Human platelets
• Format conjugation
  FITC
• Specificity
  The mouse monoclonal antibody PAC-1 recognizes an activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation.
• Research area
  CD and Related Antigens (Human)
• Storage buffer
  The reagent is provided in stabilizing Tris buffered saline (TBS) solution containing 15mM sodium azide.
• Shipping and storage
  Mouse Monoclonal Antibody against Human PAC-1, Clone: PAC-1 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120 kDa transmembrane alpha chain and 23 kDa extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin, and it is involved in platelet aggregation.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by affinity chromatography
• Datasheet
• References
  *Trikha M, Timar J, Lundy SK, Szekeres K, Cai Y, Porter AT, Honn KV: The high affinity alphaIIb beta3 integrin is involved in invasion of human melanoma cells. Cancer Res. 1997 Jun 15;57(12):2522-8., *Shattil SJ, Cunningham M, Hoxie JA: Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry. Blood. 1987 Jul;70(1):307-15. , *Shattil SJ, Hoxie JA, Cunningham M, Brass LF: Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation. J Biol Chem. 1985 Sep 15;260(20):11107-14.
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  PAC-1   monoclonal  
• Gene symbol
  DUSP2, PACC1, ADCYAP1R1, GLYR1, PSMG1, KLF6, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1
• Short name
  Anti-PAC-1 Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgM
• Alternative name
  Mouse Monoclonal to PAC-1
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3068
• Gene
  DUSP2
• Long gene name
  dual specificity phosphatase 2
• Synonyms
  • PAC-1
• GenBank acession
  • L11329
• Locus
  2q11.2
• Discovery year
  1994-12-14
• Entrez gene record
  1844
• Pubmed identfication
  • 7806236
  • 7590752
  • 12673251
• RefSeq identity
  • NM_004418
• Classification
  • MAP kinase phosphatases
• VEGA ID
  OTTHUMG00000130456

Gene info

• Identity
  HGNC:25593
• Gene
  PACC1
• Long gene name
  proton activated chloride channel 1
• Synonyms gene
  • C1orf75
  • TMEM206
• Synonyms gene name
  • chromosome 1 open reading frame 75
  • transmembrane protein 206
• Synonyms
  • FLJ10874
  • PAC
• GenBank acession
  • AK024066
• Locus
  1q32.3
• Discovery year
  2005-05-19
• Entrez gene record
  55248
• Pubmed identfication
  • 30417481
  • 31318332
• RefSeq identity
  • NM_018252
• VEGA ID
  OTTHUMG00000036751

Gene info

• Identity
  HGNC:242
• Gene
  ADCYAP1R1
• Long gene name
  ADCYAP receptor type I
• Synonyms gene name
  • adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
• Synonyms
  • PAC1
  • PACAPR
  • PAC1R
• Synonyms name
  • PACAP receptor 1
  • pituitary adenylate cyclase-activating polypeptide type 1 receptor
• Locus
  7p14.3
• Discovery year
  1994-05-18
• Entrez gene record
  117
• Pubmed identfication
  • 7902709
• RefSeq identity
  • NM_001118
• Classification
  • Vasoactive intestinal peptide family receptors
• VEGA ID
  OTTHUMG00000023884

Gene info

• Identity
  HGNC:24434
• Gene
  GLYR1
• Long gene name
  glyoxylate reductase 1 homolog
• Synonyms gene name
  • glyoxylate reductase 1 homolog (Arabidopsis)
• Synonyms
  • BM045
  • HIBDL
  • NP60
  • N-PAC
• Synonyms name
  • nuclear protein 60kDa
• GenBank acession
  • AF244907
• Locus
  16p13.3
• Discovery year
  2009-08-14
• Entrez gene record
  84656
• Pubmed identfication
  • 16352664
• RefSeq identity
  • NM_032569
• Classification
  • PWWP domain containing
• VEGA ID
  OTTHUMG00000129530

Gene info

• Identity
  HGNC:3043
• Gene
  PSMG1
• Long gene name
  proteasome assembly chaperone 1
• Synonyms gene
  • DSCR2
• Synonyms gene name
  • Down syndrome critical region gene 2
  • proteasome (prosome, macropain) assembly chaperone 1
• Synonyms
  • c21-LRP
  • LRPC21
  • PAC1
• GenBank acession
  • AJ006291
• Locus
  21q22.2
• Discovery year
  1999-09-17
• Entrez gene record
  8624
• Pubmed identfication
  • 10872820
  • 17189198
• RefSeq identity
  • NM_003720
• VEGA ID
  OTTHUMG00000066034

Gene info

• Identity
  HGNC:2235
• Gene
  KLF6
• Long gene name
  Kruppel like factor 6
• Synonyms gene
  • BCD1
  • ST12
  • COPEB
• Synonyms gene name
  • core promoter element binding protein
• Synonyms
  • CPBP
  • GBF
  • Zf9
  • PAC1
• Synonyms name
  • GC-rich binding factor
• GenBank acession
  • U51869
• Locus
  10p15.2
• Discovery year
  1997-10-16
• Entrez gene record
  1316
• Pubmed identfication
  • 9503030
  • 9685731
• Classification
  • Kruppel like factors
  • Zinc fingers C2H2-type
• VEGA ID
  OTTHUMG00000017567

Gene info

• Identity
  HGNC:5670
• Gene
  IGHVII-1-1
• Long gene name
  immunoglobulin heavy variable (II)-1-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-1-1
  • immunoglobulin heavy variable (II)-1-1 pseudogene
• Synonyms
  • IGHV(II)-1-1
• GenBank acession
  • AB019441
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28377
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152325

Gene info

• Identity
  HGNC:31499
• Gene
  MIR1-1
• Long gene name
  microRNA 1-1
• Synonyms gene
  • MIRN1-1
• Synonyms
  • hsa-mir-1-1
• Locus
  20q13.33
• Discovery year
  2004-04-23
• Entrez gene record
  406904
• RefSeq identity
  • NR_029780
• Classification
  • MicroRNA MIR1/206 family

Gene info

• Identity
  HGNC:50820
• Gene
  TRUND-NNN8-1
• Long gene name
  tRNA-undetermined (NNN) 8-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 8-1
• GenBank acession
  • HG984097
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482528
• Pubmed identfication
  • 18984615

Gene info

• Identity
  HGNC:50819
• Gene
  TRUND-NNN7-1
• Long gene name
  tRNA-undetermined (NNN) 7-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 7-1
• GenBank acession
  • HG984096
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482531
• Pubmed identfication
  • 18984615

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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