1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride
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Catalog numberI882200
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Price:
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Size10 mg
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Chemical available in other sizesPlease inquire size and price
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Stock availabilityIn Stock
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Cas number103745-39-7
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Chemical s molecular weight364.28
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Chemical s main applicationsA potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK IC50= 10.7 uM).
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Chemical s categoryProtein Kinase Inhibitors and Activators
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Other nameHA1077, Fasudil
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Chemical s formulaC14H19Cl2N3O2S
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Physical propertiesWhite to Off-White Solid
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Melting temperature>238ºC (dec.)
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Boiling temperatureNo Data Available
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Chemical s soluble inMethanol (Slightly), Water (Slightly)
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Stability conditionsNo Data Available
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Storage-20°C Freezer
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Gene target
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Gene symbolVSIR
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Short name1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1 4-diazepine, Dihydrochloride
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Alternative name1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride
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Gene info
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Identity
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Gene
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Long gene nameV-set immunoregulatory receptor
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Synonyms gene
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Synonyms gene name
- chromosome 10 open reading frame 54
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2005-10-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- B7 family
- V-set domain containing
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VEGA ID