MUC4 Antibody
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Catalog numberbs-4772R
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PricePlease ask
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Size0.1ml
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Long nameMUC4 Primary Polyclonal Antibody
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Also known asMUC4 PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenMUC4
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SpecificityThis is a highly specific antibody against MUC4.
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Modification sNone
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Modification site sUnmodified antibody
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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Immunogen range1240-1290/2169
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Subcellular locationSecreted, Cell membrane
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SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Mucin-4 alpha chain
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Gene ID number4585
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Swiss ProtQ99102
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Tested ApplicationsWB, IHC-P, IF(IHC-P)
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Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenMay play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesASGP; MUC-4; HSA276359; Mucin-4; Ascites sialoglycoprotein; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin; MUC4
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolMUC4
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Short nameAnti-MUC4
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameMUC4 Polyclonal Antibody
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Alternative techniqueantibodies
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Alternative to gene targetmucin 4, cell surface associated, ASGP and HSA276359 and MUC-4, MUC4 and IDBG-70699 and ENSG00000145113 and 4585, extracellular matrix constituent, Extracellular, Muc4 and IDBG-250337 and ENSMUSG00000079620 and 140474, MUC4 and IDBG-633795 and ENSBTAG00000014721 and
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Gene info
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Identity
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Gene
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Long gene namemucin 4, cell surface associated
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Synonyms gene name
- mucin 4, tracheobronchial
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GenBank acession
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Locus
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Discovery year1991-05-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Mucins
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data