ITGB1 (1084CT17.4.1) Monoclonal Antibody
-
Catalog numberbsm-51250M
-
PricePlease ask
-
Size0.1ml
-
-
Long nameITGB1 (1084CT17.4.1) Monoclonal Antibody
-
Also known asITGB1 (1084CT17.4.1) Monoclonal Antibody
-
CategoryPrimary Antibodies
-
ConjugationUnconjugated
-
Target AntigenITGB1
-
SpecificityThis is a highly specific antibody against ITGB1.
-
Modification sNone
-
Modification site sUnmodified antibody
-
ClonalityMonoclonal
-
Clone number1084CT17.4.1
-
SourcePurified His-tagged ITGB1 protein was used to produced this monoclonal antibody.
-
Gene ID number3688
-
Swiss ProtP05556
-
Tested ApplicationsWB
-
Recommended dilutionsWB(1:1000)
-
Cross reactivityHuman
-
Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Background of the target antigenIntegrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis.
-
Purification methodPurified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
-
Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
-
Synonym namesCD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA; Integrin beta-1; Fibronectin receptor subunit beta; Glycoprotein IIa; VLA-4 subunit beta; ITGB1
-
PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
AboutMonoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
-
French translationanticorps
-
Gene target
-
Gene symbolITGB1-DT, IATPR, ITGB1
-
Short nameAnti-ITGB1
-
TechniqueAntibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
-
HostMouse (Mus musculus)
-
IsotypeImmunoglobulin G (IgG)1
-
Alternative nameITGB1 (1084CT17.4.1) Monoclonal Antibody
-
Alternative techniqueantibodies
-
Alternative to gene targetintegrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), CD29 and FNRB and GPIIA and MDF2 and MSK12 and VLA-BETA and VLAB, ITGB1 and IDBG-68302 and ENSG00000150093 and 3688, alpha-actinin binding, Cell surfaces, Itgb1 and IDBG-201159 and ENSMUSG00000025809 and 16412, ITGB1 and IDBG-637396 and ENSBTAG00000015910 and 281876
-
Gene info
-
Identity
-
Gene
-
Long gene nameITGB1 divergent transcript
-
Locus
-
Discovery year2017-09-01
-
Entrez gene record
-
Classification
- Divergent transcripts
Gene info
-
Identity
-
Gene
-
Long gene nameITGB1 adjacent tumor promoting lncRNA
-
Synonyms
-
Locus
-
Discovery year2018-08-22
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Long non-coding RNAs with non-systematic symbols
Gene info
-
Identity
-
Gene
-
Long gene nameintegrin subunit beta 1
-
Synonyms gene
-
Synonyms gene name
- integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1988-06-27
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- CD molecules
- Integrin beta subunits
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data