MET/HGFR(Y1234/Y1235) (6AT1877) Monoclonal Antibody

• Catalog number
  bsm-51001M
• Price
  Please ask
• Size
  0.1ml

• Long name
  MET/HGFR(Y1234/Y1235) (6AT1877) Monoclonal Antibody
• Also known as
  MET/HGFR(Y1234/Y1235) (6AT1877) Monoclonal Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Bi-Phospho-MET/HGFR(Y1234/Y1235)
• Specificity
  This is a highly specific antibody against Bi-Phospho-MET/HGFR(Y1234/Y1235).
• Modification s
  Phosphorylation
• Modification site s
  Y1234/Y1235
• Clonality
  Monoclonal
• Clone number
  6AT1877
• Source
  KLH conjugated synthetic peptide corresponding to sequences in Tyr1234/1235 region of human Met and residues both Tyr1234 and Tyr1235 are phosphorylated.
• Gene ID number
  4233
• Swiss Prot
  P08581
• Tested Applications
  WB
• Recommended dilutions
  WB(1:100~500)
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.
• Purification method
  Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  HGFR; AUTS9; RCCP2; c-Met; DFNB97; Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met; MET
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  MET/HGFR   Y1234/Y1235   6AT1877   Monoclonal  
• Gene symbol
  MET, SLTM, TRM-CAT4-3, TRM-CAT5-1, TRM-CAT3-2, TRM-CAT7-1, TRM-CAT5-2, TRM-CAT2-1, TRM-CAT3-1, TRM-CAT4-2
• Short name
  Anti-Bi-Phospho-MET/HGFR(Y1234/Y1235)
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  Immunoglobulin G (IgG)1
• Alternative name
  MET/HGFR(Y1234/Y1235) (6AT1877) Monoclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7029
• Gene
  MET
• Long gene name
  MET proto-oncogene, receptor tyrosine kinase
• Synonyms gene name
  • met proto-oncogene
• Synonyms
  • HGFR
  • RCCP2
  • DFNB97
• Synonyms name
  • hepatocyte growth factor receptor
• GenBank acession
  • M35073
• Locus
  7q31
• Discovery year
  1986-01-01
• Pubmed identfication
  • 1846706
  • 1611909
  • 25941349
• Classification
  • Receptor tyrosine kinases
  • IPT domain containing
• VEGA ID
  OTTHUMG00000023299
• Locus Specific Databases
  • LRG_662

Gene info

• Identity
  HGNC:20709
• Gene
  SLTM
• Long gene name
  SAFB like transcription modulator
• Synonyms
  • Met
  • FLJ13213
• GenBank acession
  • BC046119
• Locus
  15q22.1
• Discovery year
  2005-11-08
• Entrez gene record
  79811
• RefSeq identity
  • NM_024755
• Classification
  • RNA binding motif containing
• VEGA ID
  OTTHUMG00000074033

Gene info

• Identity
  HGNC:34959
• Gene
  TRM-CAT4-3
• Long gene name
  tRNA-Met (anticodon CAT) 4-3
• Synonyms gene
  • TRNAM20
• Synonyms gene name
  • transfer RNA methionine 20 (anticodon CAU)
  • transfer RNA-Met (CAT) 4-3
• Synonyms
  • tRNA-Met-CAT-4-3
• GenBank acession
  • HG983956
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  107986682
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34869
• Gene
  TRM-CAT5-1
• Long gene name
  tRNA-Met (anticodon CAT) 5-1
• Synonyms gene
  • TRNAM16
• Synonyms gene name
  • transfer RNA methionine 16 (anticodon CAU)
  • transfer RNA-Met (CAT) 5-1
• Synonyms
  • tRNA-Met-CAT-5-1
• GenBank acession
  • HG983957
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189303
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34673
• Gene
  TRM-CAT3-2
• Long gene name
  tRNA-Met (anticodon CAT) 3-2
• Synonyms gene
  • TRNAM8
• Synonyms gene name
  • transfer RNA methionine 8 (anticodon CAU)
  • transfer RNA-Met (CAT) 3-2
• Synonyms
  • tRNA-Met-CAT-3-2
• GenBank acession
  • HG983953
• Locus
  6p22.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189111
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34645
• Gene
  TRM-CAT7-1
• Long gene name
  tRNA-Met (anticodon CAT) 7-1
• Synonyms gene
  • TRNAM5
• Synonyms gene name
  • transfer RNA methionine 5 (anticodon CAU)
  • transfer RNA-Met (CAT) 7-1
• Synonyms
  • tRNA-Met-CAT-7-1
• GenBank acession
  • HG983959
• Locus
  6p11.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189085
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:54713
• Gene
  TRM-CAT5-2
• Long gene name
  tRNA-Met (anticodon CAT) 5-2
• Synonyms
  • tRNA-Met-CAT-5-2
• Locus
  6p22.2
• Discovery year
  2019-12-06
• Entrez gene record
  107986680
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34697
• Gene
  TRM-CAT2-1
• Long gene name
  tRNA-Met (anticodon CAT) 2-1
• Synonyms gene
  • TRNAM9
• Synonyms gene name
  • transfer RNA methionine 9 (anticodon CAU)
  • transfer RNA-Met (CAT) 2-1
• Synonyms
  • tRNA-Met-CAT-2-1
• GenBank acession
  • HG983951
• Locus
  16q22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189135
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34779
• Gene
  TRM-CAT3-1
• Long gene name
  tRNA-Met (anticodon CAT) 3-1
• Synonyms gene
  • TRNAM12
• Synonyms gene name
  • transfer RNA methionine 12 (anticodon CAU)
  • transfer RNA-Met (CAT) 3-1
• Synonyms
  • tRNA-Met-CAT-3-1
• GenBank acession
  • HG983952
• Locus
  6p22.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189216
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34922
• Gene
  TRM-CAT4-2
• Long gene name
  tRNA-Met (anticodon CAT) 4-2
• Synonyms gene
  • TRNAM19
• Synonyms gene name
  • transfer RNA methionine 19 (anticodon CAU)
  • transfer RNA-Met (CAT) 4-2
• Synonyms
  • tRNA-Met-CAT-4-2
• GenBank acession
  • HG983955
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189354
• Classification
  • Cytoplasmic transfer RNAs

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products