LRP2 Antibody (Megalin)

• Catalog number
  F49460-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  LRP2 (Megalin)
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  IHC, ELISA
• Recommended dilutions
  IHC (Paraffin): 1:50-1:100
• Notes
  Titration of the Megalin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This Megalin antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P98164
• Purity
  Purified
• Description
  Low density lipoprotein (LDL) receptor-related protein (LRP), a member of the LDL receptor family, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, protease clearance, and cell migration (1). Structurally, members of the LDLR family share homology within their extracellular domains, which are highlighted by the presence of clusters of ligand-binding repeats. LRP is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis. LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes (2). All LRPs are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family (3).
• Immunogen
  A portion of amino acids 4626-4655 from the human protein was used as the immunogen for this Megalin antibody.
• Storage
  Aliquot the Megalin antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  LRP2   Megalin  
• Gene symbol
  LRP2
• Short name
  Anti-LRP2 (Megalin)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to LRP2 (Megalin)
• Alternative technique
  antibodies
• Alternative to gene target
  low density lipoprotein receptor-related protein 2, DBS and GP330, LRP2 and IDBG-74420 and ENSG00000081479 and 4036, SH3 domain binding, Plasma membranes, Lrp2 and IDBG-176227 and ENSMUSG00000027070 and 14725, LRP2 and IDBG-640945 and ENSBTAG00000004555 and 100337021

Gene info

• Identity
  HGNC:6694
• Gene
  LRP2
• Long gene name
  LDL receptor related protein 2
• Synonyms gene name
  • low density lipoprotein receptor-related protein 2
• Synonyms
  • gp330
  • DBS
• Synonyms name
  • megalin
• Locus
  2q31.1
• Discovery year
  1994-05-04
• Entrez gene record
  4036
• Pubmed identfication
  • 7959795
• RefSeq identity
  • NM_004525
• Classification
  • Low density lipoprotein receptors
• VEGA ID
  OTTHUMG00000132179
• Locus Specific Databases
  • LRG_1300

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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