MDS1 Antibody

• Catalog number
  F40040-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS pH 7.4 with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  MDS1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the MDS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This MDS1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q13465
• Purity
  Antigen affinity
• Description
  MDS1 is located at 3q26 170-400 kb upstream (telomeric) of EVI1 in the chromosomal region in which some of the breakpoints 5' of EVI1 have been mapped. MDS1 has been identified as a single gene as well as a previously unreported exon (s) of EVI1. MDS1 exists in normal tissues both as a unique transcript and as a normal fusion transcript with EVI1, with an additional 188 codons at the 5' end of the previously reported EVI1 open reading frame. In cells with translocation t (3;21), additional fusion transcripts are AML1-MDS1 and AML1-MDS1-EVI1. EVI1 and MDS1 are involved in leukemia associated with chromosomal translocation breakpoints in the region between these genes.
• Immunogen
  A portion of amino acids 81-109 from the human protein was used as the immunogen for this MDS1 antibody.
• Storage
  Aliquot the MDS1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MDS1  
• Gene symbol
  MECOM
• Short name
  Anti-MDS1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to MDS1
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3498
• Gene
  MECOM
• Long gene name
  MDS1 and EVI1 complex locus
• Synonyms gene
  • MDS1
  • EVI1
• Synonyms gene name
  • myelodysplasia syndrome 1
  • ecotropic viral integration site 1
• Synonyms
  • MDS1-EVI1
  • PRDM3
  • KMT8E
• Synonyms name
  • PR domain 3
• GenBank acession
  • S82592
  • AF164154
• Locus
  3q26.2
• Discovery year
  1990-07-10
• Entrez gene record
  2122
• Pubmed identfication
  • 2115646
  • 8171026
  • 8643684
• RefSeq identity
  • NM_005241
  • NM_004991
• Classification
  • Lysine methyltransferases
  • Zinc fingers C2H2-type
  • PR/SET domain family
• VEGA ID
  OTTHUMG00000158596
• Locus Specific Databases
  • LRG_1118

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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