GDN Antibody, ALEXA FLUOR 488

• Catalog number
  bs-9845R-A488
• Price
  Please ask
• Size
  100ul

• Long name
  GDN Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
• Also known as
  Anti-GDN PAb ALEXA FLUOR 488
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 488
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  GDN
• Specificity
  This is a highly specific antibody against GDN.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GDN/SERPINE2
• Gene ID Number
  5270
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  The serine protease inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Protease nexin-1 (PN-1) is a serpin that inactivates several proteases, including thrombin, urokinase, plasminogen activators (PA) and plasmin. It is involved in tissue remodeling, cellular invasiveness, matrix degradation and tumor growth. PN-1 expression is abundant in the nervous system, where it inhibits thrombin, thereby playing a role in neural injury and repair processes. An imbalance between PN-1 and thrombin may be a contributing factor in the pathology of Alzheimer’s disease.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  499nm/519nm
• Synonyms
  Glia derived nexin; Protease inhibitor 7; GDN; GDN_HUMAN; Glia-derived nexin; P17 antibody Peptidase inhibitor 7; Pi-7; Plasminogen activator inhibitor type 1, member 2; PN-1; PN1; PNI; Protease nexin 1; Protease nexin I; Serpin E2; Serpin peptidase inhibitor, clade E nexin, plasminogen activator inhibitor type 1, member 2; SERPINE 2; Serpine2.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-GDN has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor
• French translation
  anticorps

• Gene target
  GDN  
• Gene symbol
  MAML3, SERPINE2
• Short name
  Anti-GDN
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 488
• Alternative name
  GDN Polyclonal Antibody, ALEXA FLUOR 488
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:16272
• Gene
  MAML3
• Long gene name
  mastermind like transcriptional coactivator 3
• Synonyms gene
  • TNRC3
• Synonyms gene name
  • trinucleotide repeat containing 3
  • mastermind-like 3 (Drosophila)
• Synonyms
  • KIAA1816
  • MAM2
  • CAGH3
  • GDN
• Synonyms name
  • mastermind (drosophila)-like 3
• GenBank acession
  • AB058719
• Locus
  4q31.1
• Discovery year
  2002-11-04
• Entrez gene record
  55534
• Pubmed identfication
  • 12370315
  • 12386158
• VEGA ID
  OTTHUMG00000161441

Gene info

• Identity
  HGNC:8951
• Gene
  SERPINE2
• Long gene name
  serpin family E member 2
• Synonyms gene
  • PI7
• Synonyms gene name
  • serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
• Synonyms
  • PN1
  • GDN
  • PNI
  • nexin
• Synonyms name
  • glial-derived nexin 1
• GenBank acession
  • M17783
• Locus
  2q36.1
• Discovery year
  1994-09-01
• Entrez gene record
  5270
• Pubmed identfication
  • 7665170
  • 24172014
• RefSeq identity
  • NM_006216
• Classification
  • Serpin peptidase inhibitors
• VEGA ID
  OTTHUMG00000133163
• Locus Specific Databases
  • LRG_645

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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