Leflunomide, Immunosupressant

• Catalog number
  SIH-368-50MG
• Price
  Please ask
• Size
  50 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  75706-12-6
• Description
  Immunosupressant
• Molecular weight
  270,21 g/mol
• Primary research fields
  Cell Signaling, Neuroscience
• Other name
  5-methyl-N-[4-(trifluoromethyl) phenyl]-isoxazole-4-carboxamide
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C12H9F3N2O2
• Origin
  Synthetic
• Purity pourcentage
  >98% (TLC: 5:95, CH3OH/CH2Cl2; Rf=0.65); NMR (Conforms)
• Soluble in
  May be dissolved in DMSO (30 mg/ml); or Ethanol (27 mg/ml)
• Physical appearance
  White crystalline solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R25 – Toxic if swallowed R62 – Possible risk of impaired fertility R63 – Possible risk of harm to the unborn child Hazard Phrases: H301 – Toxic if swallowed. H315 – Causes skin irritation. H319 – Causes serious eye irritation H335 – May cause respiratory irritation Precautionary Phrases: P264 – Wash hands thoroughly after handling P280 – Wear protective gloves/protective clothing/eye protection/ face protection P301+310 - IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician P308+313 - If exposed or concerned: Get medical advice/attention
• PubChem number
  3899
• Scientific context
  Leflunomide is an Immuno-suppressant, it inhibits de novo synthesis of pyrimidine nucleotides and the activity of the protein kinase. It is a part of the known “disease-modifying anti-rheumatic drugs” (DMARD). It has been suggested that leflunomide modulates the expansion of activated autoimmune lymphocytes acting on the regression of rheumatoid conditions (1-2). It has been shown to have a double mechanism of action by slowing down and relieving the pain of rheumatoid arthritis. Studies have shown the lethal effects of Leflunomide after administration to mice in various doses (3).
• Bibliography
  1. Fukushima R., Kanamori S., Hirashiba M., et al. (2007) Reprod. Toxical. 24(3-4): 310-316. 2. Smolen JS., Emery P. (2000) Rheumatology. 39: 48-56. 3. Fox R.I., Herrman M.L., Franqou C.G., Wahl G.M., Morns R.E., Strand V. and Kirschbaum B.S. (1999) Clin Immunol 93(3): 198-208.
• Release date
  4-Apr-2013
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Leflunomide (SIH-368), a Immunosupressant. CAS #: 75706-12-6. Molecular Formula: C12H9F3N2O2. Molecular Weight: 270.21 g/mol. Chemical structure of Leflunomide, a Immunosupressant (SIH-368). CAS # 75706-12-6. Molecular Formula: C12H9F3N2O2.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.05
• Other related products

• Gene target
  Leflunomide   Immunosupressant  
• Short name
  Leflunomide, Immunosupressant
• Alternative name
  Leflunomide, Immunosupressant

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