Rabbit Anti Human L3MBTL1 Antibody-Non-conjugated

• Catalog number
  CSB-PA897111ESR2HU_50ul
• Price
  Please ask
• Size
  50ul

• Long name
  Rabbit Antibody against Human L3MBTL1, Non-conjugated
• Synonym name
  L3MBTL1 Human Antibody
• Species reactivity
  Human
• Tested applications recommended dilutions
  ELISA,IHC;Recommended dilution:IHC:1:20-1:200
• Conjugation
  Non-conjugated
• Antibody isotype
  IgG
• UniProt ID
  Q9Y468
• Format
  Liquid, diluted in buffer
• Buffer composition
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Purity
  >95%
• Purification method
  Antigen Affinity Purified Antibodies
• Antibody category
  Polyclonal Antibodies
• Immunogen type
  Recombinant human Lethal (3)malignant brain tumor-like protein 1 protein (513-752AA)
• Immunogen species
  Human
• Alias
  H-l(3)mbt,H-l(3)mbt protein,L(3)mbt-like,L(3)mbt protein homolog,L3MBTL1,KIAA0681, L3MBT, L3MBTL
• Background
  Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
• Clonality
  Polyclonal antibody
• Shipping and storage
  L3MBTL1 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
• Properties
  If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• About
  Rabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus
• French translation
  anticorps

• Gene target
  L3MBTL1   Non-conjugated  
• Gene symbol
  L3MBTL1
• Short name
  Anti-L3MBTL1
• Technique
  anti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
• Host
  Rabbit, Rabbits
• Species
  Human, Humans
• Alternative name
  L3MBTL1 Antibody
• Alternative technique
  antibodies, rabbit-anti
• Alternative to gene target
  l(3)mbt-like 1 (Drosophila), dJ138B7.3 and H-L(3)MBT and L3MBTL and ZC2HC3, L3MBTL1 and IDBG-75814 and ENSG00000185513 and 26013, identical protein binding, nuclei, L3mbtl1 and IDBG-211789 and ENSMUSG00000035576 and 241764

Gene info

• Identity
  HGNC:15905
• Gene
  L3MBTL1
• Long gene name
  L3MBTL histone methyl-lysine binding protein 1
• Synonyms gene
  • L3MBTL
• Synonyms gene name
  • l(3)mbt (Drosophila)-like
  • l(3)mbt-like (Drosophila)
  • l(3)mbt-like 1 (Drosophila)
  • L3MBTL1, histone methyl-lysine binding protein
• Synonyms
  • ZC2HC3
  • dJ138B7.3
  • DKFZp586P1522
  • KIAA0681
• Synonyms name
  • lethal (3) malignant brain tumor l(3)
• GenBank acession
  • U89358
• Locus
  20q13.12
• Discovery year
  2001-06-21
• Entrez gene record
  26013
• Pubmed identfication
  • 10445843
  • 17540172
• RefSeq identity
  • NM_032107
• Classification
  • MBT domain containing
  • Zinc fingers C2HC-type
  • Sterile alpha motif domain containing
• VEGA ID
  OTTHUMG00000032503
• Locus Specific Databases
  • LRG_1049

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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