Ku-60019

• Catalog number
  9572-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  (2R,​6S)​-2,​6-​dimethyl-​N-​[5-​[6-​(4-​morpholinyl)​-​4-​oxo-​4H-​pyran-​2-​yl]​-​9H-​thioxanthen-​2-​yl]​-​4-​morpholineacetamide
• Description
  Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC₅₀ = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective against a panel of 229 other kinases. Ku-60019 sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro.
• CAS Number
  925701-49-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₀H₃₃N₃O₅S
• Molecular Weight
  547.67
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>10 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent and reversible ATM kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  15953870
• PubChem CID Link
• SMILES
  CC1CN(CC(O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C=CC=C4C3)C5=CC(=O)C=C(O5)N6CCOCC6
• InChi
  InChI=1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+
• InChi Key
  SCELLOWTHJGVIC-BGYRXZFFSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Ku-60019  
• Short name
  Ku-60019
• Alternative name
  Ku-60019

Similar products