KDR Antibody / Kinase Insert Domain Receptor
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Catalog numberR32082
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PricePlease ask
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Size0.1mg
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CategoryAntibody
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Concentration0.5mg/ml if reconstituted with 0.2ml sterile DI water
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FormAntigen affinity purified
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ConjugationUnconjugated
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ClonePolyclonal antibody
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Recognised antigenKDR / Kinase Insert Domain Receptor
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Host animalRabbit (Oryctolagus cuniculus)
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ClonalityPolyclonal (rabbit origin)
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Species reactivityHuman (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
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Tested applicationsWB
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Recommended dilutionsWestern blot: 0.1-0.5ug/ml
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NotesOptimal dilution of the KDR antibody should be determined by the researcher.
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Intented useThis KDR antibodyis to be used only for research purposes and not for diagnostics..
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UniprotP35968
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PurityAntigen affinity
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DescriptionKDR (Kinase Insert Domain Receptor), also known as FLK1, VEGFR or VEGFR2, is a VEGF receptor. KDR is the human gene encoding it. Sait et al. (1995) likewise corrected the assignment to chromosome 4q11-q12 to the same region occupied also by PDGFRA and KIT, thus indicating the location of a cluster of receptor tyrosine kinase genes. Vascular endothelial growth factor (VEGF) is the only mitogen that specifically acts on endothelial cells. Its expression is upregulated by hypoxia, and its cell-surface receptor, known as fetal liver kinase-1 (Flk1) in mouse, is exclusively expressed in endothelial cells (Plate et al., 1993). Flk1 is the mouse homolog of KDR (Matthews et al., 1991).
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ImmunogenAmino acids LDLPRLSIQKDILTIKANTTLQITCRGQRDLD of human KDR were used as the immunogen for the KDR antibody.
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StorageAfter reconstitution, the KDR antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
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PropertiesIf you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Additional descriptionThe receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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French translationanticorps
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Gene target
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Gene symbolKDR
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Short nameAnti-KDR / Kinase Insert Domain Receptor
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative nameAntibodies to KDR / Kinase Insert Domain Receptor
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Alternative techniqueantibodies
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Alternative to gene targetkinase insert domain receptor (a type III receptor tyrosine kinase), CD309 and FLK1 and VEGFR and VEGFR2, KDR and IDBG-19161 and ENSG00000128052 and 3791, transferase activity, nuclei, Kdr and IDBG-172240 and ENSMUSG00000062960 and 16542, KDR and IDBG-642352 and ENSBTAG00000000782 and 407170
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Gene info
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Identity
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Gene
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Long gene namekinase insert domain receptor
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Synonyms gene name
- kinase insert domain receptor (a type III receptor tyrosine kinase)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1991-07-10
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Entrez gene record
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Pubmed identfication
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Classification
- Receptor tyrosine kinases
- CD molecules
- I-set domain containing
- V-set domain containing
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data