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Target antigen
Jagged 2
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, mouse, rat
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Analyses
WB
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Immunogen
E.coli-derived human Jagged 2 recombinant protein (Position: R962-E1238). Human Jagged 2 shares 85% and 79% amino acid (aa) sequence identity with mouse and rat Jagged 2, respectively.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the Jagged 2 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The Jagged 2 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
Protein jagged-2, also known as SER2, is a protein that in humans is encoded by the JAG2 gene. It is mapped to 14q32.33. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Notch ligands Delta1 and JAG2 are subject to presenilin-dependent, intramembranous gamma-secretase processing, resulting in the production of soluble intracellular derivatives. JAG2 can promote the growth and dissemination of uveal melanoma cells.
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Related articles
1. Asnaghi, L., Handa, J. T., Merbs, S. L., Harbour, J. W., Eberhart, C. G. A role for Jag2 in promoting uveal melanoma dissemination and growth. Invest. Ophthal. Vis. Sci. 54: 295-306, 2013. 2. Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L (April 2000). "Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene". Genomics 63 (1): 133–8. 3. Ikeuchi, T., Sisodia, S. S. The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent 'gamma-secretase' cleavage. J. Biol. Chem. 278: 7751-7754, 2003. 4. Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J (October 1997). "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor". Mol Cell Biol 17 (10): 6057–67.
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Gene Name
JAG2
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Protein Name
Protein jagged-2
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Gene Full Name
jagged 2
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Synonyms
D12Ggc2e antibody|HJ 2 antibody|HJ2 antibody|JAG 2 antibody|JAG2 antibody|Jagged 2 precursor antibody|Jagged2 antibody|Protein jagged 2 antibody|SER2 antibody|Syndactylism antibody
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Uniprot ID
Q9Y219
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Entrez GeneID
3714
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
