HVEM-Fc Recombinant Protein

• Catalog number
  40-316
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• About recombinant protein
  HVEM belongs to the TNF Receptor superfamily of transmembrane proteins and plays a role in the activation of T-cells and other lymphocytes. It is expressed in various cells and tissues including spleen, thymus, lung, macrophages, and T-cells. HVEM activation induces a signaling cascade which results in induction of transcription factors NF-kappaB and AP-1. LIGHT (TNFSF14) and TNF-beta (TNFSF1) function as the ligands for HVEM, which can also bind specifically to herpes simplex virus glycoprotein D. Soluble HVEM can act as a "receptor decoy” resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-beta. Recombinant human HVEM-Fc Chimera is a 376 amino acid fusion protein containing an N-terminal domain corresponding to the extracellular region of HVEM and a C-terminal domain corresponding to residues 102 to 330 of human IgG1.
• Other name of the recombinant
  TR2, ATAR, HVEA, HVEM, CD270, LIGHTR, UNQ329/PRO509, Tumor necrosis factor receptor superfamily member 14, Herpes virus entry mediator A, Herpesvirus entry mediator A
• Recombinant in
  High-5 Insect cells
• SEQUENCE
  LPSCKEDEYP VGSECCPKCS PGYRVKEACG ELTGTVCEPC PPGTYIAHLN GLSKCLQCQM CDPAMGLRAS RNCSRTENAV CGCSPGHFCI VQDGDHCAAC RAYATSSPGQ RVQKGGTESQ DTLCQNCPPG TFSPNGTLEE CQHQTKRSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK
• Activity
  Biological activity was determined by its ability to neutralize 0.25 ng/mL of hTNFB induced cytotoxicity on murine L929 cells. The expected ED50 for this effect is 1.3 - 1.9 μg/mL of HVEM - Fc.
• Keep at
  The lyophilized HVEM-Fc recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted HVEM-Fc is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing HVEM-Fc recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  23200041
• Accession nr
  NP_003811.2
• Pureity
  Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
• About
  This product is for research use only.
• Protein s origin
  Human
• Vial
  Lyophilized
• NCBI ID
  8764
• Gene name
  tumor necrosis factor receptor superfamily, member 14
• Source
  Homo sapiens
• Uniprot
  Q92956
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  HVEM-Fc   Protein  
• Gene symbol
  TNFRSF14
• Short name
  HVEM-Fc Recombinant Protein
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  HVEM-fragment c Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:26966
• Gene
  TNFRSF14-AS1
• Long gene name
  TNFRSF14 antisense RNA 1
• Synonyms
  • ENST00000416860.2
• Locus
  1p36.32
• Discovery year
  2017-04-27
• Entrez gene record
  115110
• Pubmed identfication
  • 28418905
• RefSeq identity
  • NR_037844
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:11912
• Gene
  TNFRSF14
• Long gene name
  TNF receptor superfamily member 14
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
  • tumor necrosis factor receptor superfamily, member 14
• Synonyms
  • HVEM
  • ATAR
  • TR2
  • LIGHTR
  • HVEA
  • CD270
• Synonyms name
  • herpesvirus entry mediator
• GenBank acession
  • U70321
• Locus
  1p36.32
• Discovery year
  1998-12-04
• Entrez gene record
  8764
• Pubmed identfication
  • 8898196
  • 9162061
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000000792

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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