GSK-J4 (Free base)

• Catalog number
  2762-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
• Description
  GSK- J4 is cell-permeable ethyl ester of GSK-J1 (Cat. Nos. 2260 & 2761). Acts as a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC₅₀ = 9 μM for the inhibition of TNFα release). Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.
• CAS Number
  1373423-53-0
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₂₄H₂₇N₅O₂
• Molecular Weight
  417.5
• Cell Permeable
  Y
• Purity
  ≥99% by TLC
• Solubilities
  DMSO (~ 40 mg/ml) or EtOH (~ 40 mg/ml)
• Handling
  Protect from light and moisture
• Tag Line
  A histone demethylase JMJD3/UTX inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• MDL Number
  MFCD22683852
• PubChem CID
  71729975
• PubChem CID Link
• SMILES
  CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4
• InChi
  InChI=1S/C24H27N5O2/c1-2-31-23(30)10-14-26-21-17-22(28-24(27-21)20-9-5-6-13-25-20)29-15-11-18-7-3-4-8-19(18)12-16-29/h3-9,13,17H,2,10-12,14-16H2,1H3,(H,26,27,28)
• InChi Key
  WBKCKEHGXNWYMO-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  GSK-J4   Free   base  
• Short name
  GSK-J4 (Free base)
• Alternative name
  GSK-J4 (Free base)

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