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GALR1 Antibody Conjugated

GALR1 Antibody Conjugated is available 8 times from Bioss primary conjugated antibodies labs

bs-9927R-Biotin | GALR1 Antibody, Biotin Conjugated size: 0.1ml | 383.12 USD

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bs-9927R-Cy3 | GALR1 Antibody, Cy3 Conjugated size: 0.1ml | 402.68 USD

Long name GALR1 Polyclonal Antibody, Cy3 Conjugated
Conjugation Cy3
Tested applications FCM, IF(IHC-P)
Recommended dilutions FCM(1:20-100), IF(IHC-P)(1:50-200)
Storage conditions Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
Excitation Emission 512,550nm/570,615nm
Properties If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the GALR1 Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.
Additional conjugation cy3 conjugation kit
French translation anticorps
Gene targetGALR1 Conjugated
Short name GALR1 Antibody, Conjugated
Technique Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
Label Cy3
Alternative name GALR1 (Antibody to), cyanine 3 coupled
1. Gene info
Identity4132
GeneGALR1
Long gene name galanin receptor 1
Synonyms gene
GenBank acession
Locus18q23
Discovery year 1994-12-19
Entrez gene record2587
Pubmed identfication
Classification
  • Galanin receptors
Havana BLAST/BLATOTTHUMG00000132875
MeSH Data
Concept
Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
Additional information
PubMedEvidence is provided for an inhibitory function for the neuropeptide galanin acting on galanin receptor 1 (GALR1) in nociception and neuropathic pain after peripheral nerve injury in mice.
Mice overexpressing galanin had a moderate heat hypoalgesia, reduced spinal sensitization after repetitive C-fiber stimulation and reduced development of neuropathic pain-like behavior after sciatic nerve injury
excess GAL in cognitive impairment is relevant to the overexpression of GAL in the basal forebrain during the progression of Alzheimer's disease
The expression of mRNA galanin is increased following chronic restraint stress.
Homozygous Galr1-/- mice are viable, capable of breeding, and exhibit no significant difference in growth rate. They have reduced circulating levels of insulin-like growth factor-I (IGF-I) and exhibit spontaneous tonic-clonic seizures.
The distribution of galanin receptor 1 messenger RNA in the mouse brain is abundantly expressed in many brain regions, including numerous hypothalamic and other forebrain regions associated with neuroendocrine function.
GAL-R1 knockout mice are unimpaired on a number of tests of learning and memory with the exception of the trace version of cued fear conditioning.
GalR1 knockout mice showed no difference with respect to acute nociception, but showed a modest tendency towards increased hyperalgesia after tissue injury and inflammation
In GalR1KO mice, a high dose of galanin failed to induce any of the above effects, suggesting the pivotal role of GalR1 in decreased locomotor activity and stress-resistant effects caused by galanin i.c.v. injection studied here.
Galanin receptor 1 deletion exacerbates hippocampal neuronal loss after systemic kainate administration in mice
Entrez Genegalanin receptor 1  (GALR1)

bs-9927R-Cy5 | GALR1 Antibody, Cy5 Conjugated size: 0.1ml | 402.68 USD

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bs-9927R-Cy5.5 | GALR1 Antibody, Cy5.5 Conjugated size: 0.1ml | 402.68 USD

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bs-9927R-Cy7 | GALR1 Antibody, Cy7 Conjugated size: 0.1ml | 402.68 USD

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bs-9927R-FITC | GALR1 Antibody, FITC Conjugated size: 0.1ml | 383.12 USD

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bs-9927R-HRP | GALR1 Antibody, HRP Conjugated size: 0.1ml | 402.68 USD

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bs-9927R-PE | GALR1 Antibody, PE Conjugated size: 0.1ml | 423.38 USD

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Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Target Antigen GALR1
Specificity This is a highly specific antibody against GALR1.
Modification Unmodified
Modification site None
Clonality Polyclonal
Clone Polyclonal antibody
Concentration 1ug per 1ul
Subcellular location Extracellular
Source KLH conjugated synthetic peptide derived from human GALR1
Gene ID number 2587
Crossreactivity Human
Crossreactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Antigen background GALR1 is a G-protein-coupled receptor for the neuropeptide galanin that influences endocrine secretions, intestinal motility, memory, weight, and pain perception. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, and in peripheral sites such as the small intestine and heart. The rat galanin receptor cDNA cloned from an insulinoma cell line is a predicted 346-amino acid G protein-coupled receptor with 92% homology to the human GALR1.
Purification method This antibody was purified via Protein A.
Synonyms GAL1R; galanin receptor 1; Galanin receptor; Galanin receptor type 1; GALNR; GALNR1; GALR1; GALR1_HUMAN.
Alternative technique antibodies
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