FTI 277 hydrochloride

FTI 277 hydrochloride is available 4 times from Biovision labs

2874-25 | FTI-277 hydrochloridesize: 25 mg | 684.92 USD

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2874-5 | FTI-277 hydrochloridesize: 5 mg | 300.01 USD

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2874-25 | FTI-277 hydrochloride for cell activationsize: 25 mg | 616.99 USD

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2874-5 | FTI-277 hydrochloride for cell activationsize: 5 mg | 198.12 USD

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  • Alternate Name/Synonyms
    N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester hydrochloride
  • Appearance
    Off-white solid
  • Formulation
    N/A
  • CAS Number
    180977-34-8
  • Peptide sequence
    N/A
  • Molecular Formula
    C₂₂H₂₉N₃O₃S₂.HCl
  • Molecular Weight
    484.07
  • Purity
    ≥98% by HPLC
  • Solubility/Reconstitution Instructions
    DMSO (>50 mg/ml)
  • Handling
    Protect from air and moisture
  • Tagline
    A potent and selective farnesyltransferase (FTase) inhibitor
  • Storage Temp.
    -20°C
  • Shipping Conditions
    gel pack
  • Shelf Life
    36 months
  • MDL Number
    N/A
  • PubChem CID
    3005532
  • Category
    Biochemicals
  • Description
    FTI-277 is a potent and selective farnesyltransferase (FTase) inhibitor (IC50 = 0.5 nM). It potently inhibits (IC₅₀ = 100 nM) H-Ras, but not the geranylgeranylated Rap1A processing in whole cells. FTI-277 blocks constitutive activation of mitogen-activated protein kinase (MAPK) in H-RasF, but not H-RasGG, or Raf-transformed cells.
  • CAS number
    180977-34-8
  • Molecular weight
    484.07
  • Other name
      N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester hydrochloride
  • Molecular formula
    C₂₂H₂₉N₃O₃S₂.HCl
  • Physical appearance
    Off-white solid
  • Supplied with
    N/A
  • Is this a salt?
    No
  • Is it cell-permeable?
    Yes
  • Purification
    ≥98% by HPLC
  • Reconstitute instructions
    DMSO (>50 mg/ml)
  • Storage condition
    -20°C
  • Shipping condition
    gel pack
  • Maximum time for storage
    36 months
  • Storage instructions
    Protect from air and moisture
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