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Stock availabilitIn Stock
In Stock
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CAS number
658084-64-1
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Description
NAD biosynthesis inhibitor
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Molecular weight
428 g/mol
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Primary research fields
Cell Signaling, Epigenetics
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Other name
(E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)acrylamide, FK866 hydrochloride hydrate, K22.175
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C24H29N3O2•HCl
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Origin
Synthetic
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Purity pourcentage
>98% (TLC), NMR conforms
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Soluble in
Soluble in 40 mg/ml Water
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Physical appearance
White Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution- Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302 – Harmful if swallowed.
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PubChem number
6914657
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Scientific context
Nicotinamide phosphoribosyltransferase inhibitor (Ki=0.4 nM). Induces tumor cell apoptosis. Extends lifespan of human cells. Cell permeable.
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Bibliography
1. Hasmann M., et al. (2003) Cancer Res. 63: 7436. 2. van der Veer E., et al. (2007) J. Biol. Chem. 282: 10841.
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Release date
1-Aug-2012
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of FK-866 HCl (SIH-354), a NAD biosynth inhib. (SIR down regulator). CAS #: 658084-64-1. Molecular Formula: C24H29N3O2.HCl. Molecular Weight: 428 g/mol. Chemical structure of FK-866 HCl, a NAD biosynth inhib. (SIR down regulator) (SIH-354). CAS # 658084-64-1. Molecular Formula: C24H29N3O2.HCl.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
