FE65 Antibody

• Catalog number
  bs-0110R
• Price
  Please ask
• Size
  0.1ml

• Long name
  FE65 Primary Polyclonal Antibody
• Also known as
  FE65 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  FE65
• Specificity
  This is a highly specific antibody against FE65.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  225-265/710
• Subcellular location
  Cytoplasm, Nucleus, Cell membrane
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Fe65 protein
• Gene ID number
  322
• Swiss Prot
  O00213
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  RIR; FE65; MGC:9072; Amyloid beta A4 precursor protein-binding family B member 1; Protein Fe65; APBB1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  FE65  
• Gene symbol
  APBB1
• Short name
  Anti-FE65
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  FE65 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:581
• Gene
  APBB1
• Long gene name
  amyloid beta precursor protein binding family B member 1
• Synonyms gene
  • RIR
• Synonyms gene name
  • amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
• Synonyms
  • Fe65
• GenBank acession
  • L77864
• Locus
  11p15.4
• Discovery year
  1997-03-27
• Entrez gene record
  322
• Pubmed identfication
  • 8955346
  • 8894693
• RefSeq identity
  • NM_001164
• VEGA ID
  OTTHUMG00000165454

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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