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Products_type
Antibody
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Products_short_name
[FceRI, alpha]
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Products_name_syn
[Anti -FceRI, alpha (Fc epsilon RI alpha, FCE1A, FCER1A, High Affinity Immunoglobulin epsilon Receptor Subunit alpha, IgE Receptor)]
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Other_names
[Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; High affinity immunoglobulin epsilon receptor subunit alpha; high affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; Fc epsilon RI alpha-chain; igE Fc receptor subunit alpha; Fc IgE receptor, alpha polypeptide; high affinity immunoglobulin epsilon receptor alpha-subunit; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc-epsilon RI-alpha; FcERI; IgE Fc receptor subunit alpha]
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Other_gene_names
[FCER1A; FCER1A; FCE1A; FcERI; FCE1A; FcERI]
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Clonality
Monoclonal
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Clone
[10C204]
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Reactivity
Human
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Specificity
Recognizes human Human Fc Epsilon R1, alpha.
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Purity
Affinity Purified Purified by Protein G affinity chromatography.
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Form
Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
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Storage_stability
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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Tested_application
ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS), Immunofluorescence (IF)
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Test
A high affinity purification column was use to purify FceRI, alpha (Fc epsilon RI alpha, FCE1A, FCER1A, Immunoglobulin epsilon Receptor Subunit alpha, IgE Receptor) by MyBioSource by chromatographic size exclusion.
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Description
The FceRI, alpha (Fc epsilon RI alpha, FCE1A, FCER1A, Immunoglobulin epsilon Receptor Subunit alpha, IgE Receptor) is a α- or alpha protein sometimes glycoprotein present in blood. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Properties
Immunoglobulin E (IgE) kappa or Fc specific antibody is a kind of antibody (or immunoglobulin (Ig) "isotype") that has only been found in mammals. IgE is synthesized by plasma cells. Monomers of IgE consist of two heavy chains (ε chain) and two light chains, with the ε chain containing 4 Ig-like constant domains (Cε1-Cε4). IgEs play a role in allergy and response to parasite infection. High levels of IgEs caused by parasites can lower the allergic reaction of patients to allergens common present in the human environment. As such the parasite history of an allergic patient needs to be taken in consideration as a positive factor.
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Gene target
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Gene symbol
FCER1A
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Short name
FceRI, alpha (Fc epsilon RI alpha, FCE1A, FCER1A, Immunoglobulin epsilon Receptor Subunit alpha, IgE Receptor)
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Technique
affinity, IgE, FC, IgEs
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Host
Mouse
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Isotype
IgG2b, IgE
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Alternative name
FceRI, a (fragment c epsilon RI a, FCE1A, fragment c fragment on immunoglobuline E, high affinity I, receptor to measure; a polypeptide, High protein Immunoglobulin epsilon Receptor functionnal sequence a, immunoglobuline E Receptor)
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Alternative technique
immunoglobulin-e
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Alternative to gene target
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, FCE1A and FcERI, FCER1A and IDBG-103887 and ENSG00000179639 and 2205, IgE binding, Cell surfaces, Fcer1a and IDBG-205782 and ENSMUSG00000005339 and 14125, FCER1A and IDBG-630768 and ENSBTAG00000012887 and 506783
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