Factor Xa Inhibitor Screening Kit (Fluorometric)

• Catalog number
  K362-100
• Price
  Please ask
• Size
  100 assays

• Description
  Simple assay to screen Factor Xa inhibitors
• Summary
  • Detection method- Fluorescence (Ex/Em = 350/450 nm) • Applications: - Screening potential inhibitors of Factor Xa - Characterizing/studying Factor Xa inhibitors in plasma samples
• Detection Method
  Fluorescence (Ex/Em = 350/450 nm)
• Applications
  • Screening potential inhibitors of Factor Xa • Characterizing/studying Factor Xa inhibitors in plasma samples
• Features Benefits
  • Simple and reliable test to screen/study/characterize Fxa inhibitors • High-throughput • Includes Inhibitor Control (GGACK Dihydrochloride)
• Storage Conditions
  -20°C
• Shipping Conditions
  gel pack
• Shelf life
  12 months
• Background
  Factor Xa (FXa) is the activated form of the coagulation factor X (Stuart-Power factor, thrombokinase, prothrombinase, thromboplastin, E.C.3.4.21.6). Factor X, a serine endopeptidase, plays an important role at several stages of the coagulation pathway. It acts by converting prothrombin into active thrombin by complexing with activated co-factor V in the prothrombinase complex. Unfractionated heparin and various low molecular weight heparins bind to plasma cofactor Antithrombin to inactivate several coagulation factors including factor Xa. Biovision's Factor Xa inhibitor screening kit utilizes the ability of Factor Xa to cleave a synthetic substrate thereby releasing a fluorophore, AMC, which can be quantified by a fluorescence reader. In the presence of an inhibitor, the extent of the cleavage reaction is reduced or completely abolished. The loss in the fluorescence intensity can be correlated to the amount of inhibitor present in the assay solution. The Factor Xa Inhibitor Screening Kit is a simple, straightforward, high-throughput assay to screen Factor Xa inhibitors.
• Data Sheet Link
• Additional description
  Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Factor   Inhibitor   Screening   Kit   Fluorometric  
• Short name
  Factor Xa Inhibitor Screening Kit (Fluorometric)
• Alternative name
  Factor Xa suppressor detection reagent (fluorescence)
• Alternative technique
  kits
• Alternative to gene target
  v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832

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