EPZ 5676 for cell activation

EPZ 5676 for cell activation is available 2 times from Biovision labs

2382-1 | EPZ-5676 for cell activationsize: 1 mg | 211.87 USD

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2382-5 | EPZ-5676 for cell activationsize: 5 mg | 669.79 USD

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  • Description
    A potent and selective inhibitor of DOT1L methyltransferase (Ki = 80 pM). EPZ-5676 displays 37,000-fold selectivity over all other tested methyltransferases. It inhibits H3K79 methylation and MLL-fusion target gene expression and displays potent cell killing selective for acute leukemia lines bearing MLL translocations.
  • Peptide sequence
    N/A
  • CAS number
    1380288-87-8
  • Molecular weight
    562.71
  • Category
    Biochemicals
  • Other name
    (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol  
  • Molecular formula
    C₃₀H₄₂N₈O₃
  • Physical appearance
    Crystalline solid
  • Supplied with
    N/A
  • Is this a salt?
    No
  • Is it cell-permeable?
    Yes
  • Purification
    ≥98% by HPLC
  • Reconstitute instructions
    DMSO (~ 25 mg/ml)
  • Storage condition
    -20 ̊C
  • Shipping condition
    gel pack
  • Maximum time for storage
    36 months
  • Storage instructions
    Protect from light and air
  • Additional description
    For cells, cell lines and tissues in culture till half confluency.
  • Gene target
  • Short name
    EPZ-5676 for activation
  • Technique
    activation
  • Alternative name
    EPZ-5676 to measure cellular activation
  • Tissue
    cell
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