EMD-1214063

Alternative_name

3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
Description

EMD-1214063 is a potent and selective c-Met inhibitor (IC₅₀ = 4 nM), that displays >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer.
CAS Number

1100598-32-0
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₉H₂₈N₆O₂
Molecular Weight

492.57
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A potent and selective c-Met inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

25171648
PubChem CID Link
SMILES

CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC(=CC=C3)CN4C(=O)C=CC(=N4)C5=CC=CC(=C5)C#N
InChi

InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3
InChi Key

AHYMHWXQRWRBKT-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes