ELAVL2 + ELAVL4 Antibody

• Catalog number
  bs-11743R
• Price
  Please ask
• Size
  0.1ml

• Long name
  ELAVL2 + ELAVL4 Primary Polyclonal Antibody
• Also known as
  ELAVL2 + ELAVL4 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  ELAVL2 + ELAVL4
• Specificity
  This is a highly specific antibody against ELAVL2 + ELAVL4.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  70-120/359
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ELAVL2
• Gene ID number
  19931996
• Swiss Prot
  Q12926,P25378
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  The Elav-like genes encode for a family of RNA-binding proteins. Elav, a Drosophila protein and the first described member, is expressed immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. Several mammalian Elav-like proteins, designated HuC, HuD and Hel-N1, are also expressed in postmitotic neurons. An additional mammalian homolog, HuR, which is also designated HuA, is ubiquitously expressed and is also overexpressed in a wide variety of tumors. Characteristically, these homologs all contain three RNA recognition motifs (RRM) and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation. When Elav-like proteins associate with these ARE sites this degradation is inhibited, leading to an increased stability of the corresponding transcript. Elav proteins function within the nucleus, and they are shuttled between the nucleus and cytoplasm by a nuclear export signal, which is a regulatory feature of the Elav-like proteins as it limits their accessibility to ARE sites.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  ELAV like 4; ELAV like protein 2; ELAV like protein 4; ELAVL 2; ELAVL 4; HELN1; Hu antigen B; Hu antigen D; HUB; HUD; ELAV2_HUMAN; ELAV4_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ELAVL2   ELAVL4  
• Gene symbol
  ELAVL4-AS1, ELAVL4, ELAVL2
• Short name
  Anti-ELAVL2 + ELAVL4
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  ELAVL2 + ELAVL4 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:40210
• Gene
  ELAVL4-AS1
• Long gene name
  ELAVL4 antisense RNA 1
• Locus
  1p33
• Discovery year
  2019-07-25
• Entrez gene record
  107984955
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:3315
• Gene
  ELAVL4
• Long gene name
  ELAV like RNA binding protein 4
• Synonyms gene
  • HUD
• Synonyms gene name
  • ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
  • ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4
  • ELAV like neuron-specific RNA binding protein 4
• Synonyms
  • PNEM
• Synonyms name
  • Hu antigen D
• GenBank acession
  • AY033998
• Locus
  1p33-p32.3
• Discovery year
  1993-07-12
• Entrez gene record
  1996
• Pubmed identfication
  • 8222755
• RefSeq identity
  • NM_021952
• Classification
  • RNA binding motif containing
• VEGA ID
  OTTHUMG00000007877

Gene info

• Identity
  HGNC:3313
• Gene
  ELAVL2
• Long gene name
  ELAV like RNA binding protein 2
• Synonyms gene name
  • ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2
  • ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
  • ELAV like neuron-specific RNA binding protein 2
• Synonyms
  • HuB
  • HEL-N1
• Synonyms name
  • Hu antigen B
• GenBank acession
  • BC030692
• Locus
  9p21.3
• Discovery year
  1996-11-15
• Entrez gene record
  1993
• Pubmed identfication
  • 8812435
• RefSeq identity
  • NM_004432
• Classification
  • RNA binding motif containing
• VEGA ID
  OTTHUMG00000019700

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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