Dnmt3L Antibody

• Catalog number
  bs-13026R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Dnmt3L Primary Polyclonal Antibody
• Also known as
  Dnmt3L PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Dnmt3L
• Specificity
  This is a highly specific antibody against Dnmt3L.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Dnmt3L
• Gene ID number
  29947
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines, thereby repressing expression of the target gene. Dnmt3L (DNA (cytosine-5)-methyltransferase 3-like) is a 387 amino acid protein that contains one ADD-type zinc finger and is a member of the Dnmt family. Localized to the nucleus and expressed at lows levels in thymus, testis and ovary, Dnmt3L does not exhibit DNA methyltransferase activity, but is able to stimulate de novo methylation by Dnmt3 and is thought to play a key role in the establishment of genomic imprints. Additionally, Dnmt3L interacts with histone deacetylase 1 (HDAC1) and, through this interaction, mediates transcriptional repression. Multiple isoforms of Dnmt3L exist due to alternative splicing events.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Cytosine 5 methyltransferase 3 like protein; DNA cytosine 5 methyltransferase 3 like; DNA cytosine-5-methyltransferase 3-like; DNA Cytosine 5 Methyltransferase 3 Like Protein; DNA Methyltransferase 3 Like Protein; DNM3L_HUMAN; Dnmt 3L; Dnmt3l; Human cytosine 5 methyltransferase 3 like protein; MGC1090.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Dnmt3L  
• Gene symbol
  DNMT3L-AS1, DNMT3L
• Short name
  Anti-Dnmt3L
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Dnmt3L Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:40189
• Gene
  DNMT3L-AS1
• Long gene name
  DNMT3L antisense RNA 1
• Locus
  21q22.3
• Discovery year
  2019-07-25
• Entrez gene record
  105372833
• RefSeq identity
  • NR_135514
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:2980
• Gene
  DNMT3L
• Long gene name
  DNA methyltransferase 3 like
• Synonyms gene name
  • DNA (cytosine-5-)-methyltransferase 3-like
• Synonyms
  • MGC1090
• Synonyms name
  • cytosine-5-methyltransferase 3-like protein
• GenBank acession
  • AF194032
• Locus
  21q22.3
• Discovery year
  2000-05-23
• Entrez gene record
  29947
• Pubmed identfication
  • 10857753
• RefSeq identity
  • NM_013369
• Classification
  • 7BS C5-cytosine DNA/RNA methyltransferases
• VEGA ID
  OTTHUMG00000086914

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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