GnRH-Receptor / LH-RH Receptor Mouse Monoclonal Antibody
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Catalog numberMBS438546
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PricePlease ask
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Size0.1 mg (Without BSA & Azide at 1mg/mL)
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Products_typeAntibody
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Products_short_name[GnRH-Receptor / LH-RH Receptor]
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Products_name_syn[GnRH receptor, GnRH-R, GNRHR1, gonadotropin-releasing hormone (type 1) receptor 1, GRHR, HH7, leutinizing-releasing hormone receptor, LHRHR, LRHR, luliberin receptor, luteinizing hormone releasing hormone receptor, Type I GnRH receptor]
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Other_names[gonadotropin-releasing hormone receptor isoform 1; Gonadotropin-releasing hormone receptor; gonadotropin-releasing hormone receptor; gonadotropin releasing hormone receptor]
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Products_gene_name[GNRHR]
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Products_gene_name_syn[LHCGR]
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Other_gene_names[GNRHR; GNRHR; HH7; GRHR; LRHR; LHRHR; GNRHR1; GRHR; GnRH receptor; GnRH-R]
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ClonalityMonoclonal
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Clone[GNRHR/768]
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ReactivityHuman
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SpecificityRecognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.
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Form200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
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Storage_stabilityAntibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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Tested_applicationFlow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
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PropertiesIf you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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AboutMonoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus
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DescriptionThe receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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French translationanticorps
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Gene target
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Gene symbolGNRH1, LHX2, RHCE, DDX21, PIAS1, RHD, DDX50
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Short nameGnRH-Receptor / LH-RH Receptor Mouse Monoclonal Antibody
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TechniqueMouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
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HostMouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
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IsotypeIgG1, kappa
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SpeciesMouse, Mouses
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Alternative nameGnRH-Receptor / LH-RH Receptor Mouse monoclonal (antibody to-)
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Alternative techniqueantibodies, murine
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Gene info
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Identity
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Gene
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Long gene namegonadotropin releasing hormone 1
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Synonyms gene
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Synonyms gene name
- leuteinizing-releasing hormone
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Synonyms name
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GenBank acession
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Locus
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Discovery year1993-12-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Neuropeptides
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameLIM homeobox 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-04-15
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Entrez gene record
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Pubmed identfication
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Classification
- LIM class homeoboxes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRh blood group CcEe antigens
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Synonyms gene
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Synonyms gene name
- Rhesus blood group, CcEe antigens
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-10-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Blood group antigens
- CD molecules
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameDExD-box helicase 21
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Synonyms gene name
- DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21
- DEAD-box helicase 21
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-12-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- DEAD-box helicases
- B-WICH chromatin-remodelling complex subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameprotein inhibitor of activated STAT 1
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Synonyms gene
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Synonyms gene name
- DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-11-06
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Entrez gene record
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Pubmed identfication
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Classification
- Zinc fingers MIZ-type
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRh blood group D antigen
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Synonyms gene
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Synonyms gene name
- Rhesus blood group, D antigen
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Synonyms
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Blood group antigens
- CD molecules
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameDExD-box helicase 50
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Synonyms gene name
- DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
- DEAD-box helicase 50
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-06-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- DEAD-box helicases
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data