DDB2 Antibody

• Catalog number
  R32291
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  DDB2
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.1-0.5ug/ml
• Notes
  Optimal dilution of the DDB2 antibody should be determined by the researcher.
• Intented use
  This DDB2 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q92466
• Purity
  Antigen affinity
• Description
  DNA damage-binding protein 2 is a protein that in humans is encoded by the DDB2 gene. This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. And this subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
• Immunogen
  Amino acids 1-115 of human DDB2 were used as the immunogen for the DDB2 antibody.
• Storage
  After reconstitution, the DDB2 antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  DDB2  
• Gene symbol
  DDB2
• Short name
  Anti-DDB2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to DDB2
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:2718
• Gene
  DDB2
• Long gene name
  damage specific DNA binding protein 2
• Synonyms gene name
  • damage-specific DNA binding protein 2 (48kD)
• Synonyms
  • DDBB
  • UV-DDB2
  • FLJ34321
  • XPE
• Synonyms name
  • xeroderma pigmentosum group E protein
  • UV-damaged DNA-binding protein 2
  • DDB p48 subunit
• Locus
  11p11.2
• Discovery year
  1995-07-06
• Entrez gene record
  1643
• Pubmed identfication
  • 8407967
  • 8530102
• RefSeq identity
  • NM_000107
• Classification
  • Xeroderma pigmentosum complementation groups
  • Nucleotide excision repair
  • WD repeat domain containing
• VEGA ID
  OTTHUMG00000187453
• Locus Specific Databases
  • LRG_467

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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