B7-H4 /VTCN1, mouse recombinant
#
-
Catalog numberP1107-10
-
Price:
-
Size10 ug
-
-
SynonymsV-set Domain-containing T Cell Activation Inhibitor 1, VTCN1, B7h.5, Immune Costimulatory Protein B7-H4, T Cell Costimulatory Molecule B7x, Protein B7S1
-
Alternative_namesV-set Domain-containing T Cell Activation Inhibitor 1, VTCN1, B7h.5, Immune Costimulatory Protein B7-H4, T Cell Costimulatory Molecule B7x, Protein B7S1
-
DescriptionNegatively regulates T-cell-mediated immune response and is involved in promoting epithelial cell transformation
-
RecombinantYes
-
SourceCHO cells
-
Purity by SDS PAGE≥98%
-
AssaySDS-PAGE
-
Endotoxin Level< 0.06 EU/ug
-
Activity Specifications test methodMeasured by its ability to inhibit anti-CD3-induced proliferation of stimulated mouse T cells
-
Biological activityMeasured by its ability to inhibit anti-CD3-induced proliferation of stimulated mouse T cells
-
Storage Temp-20°C
-
ShippingGel pack
-
Shelf Life12 months
-
AppearanceLyophilized
-
Physical form descriptionLyophilized from 0.2 um-filtered solution in PBS
-
Reconstitution InstructionsReconstitute with 100 µl sterile water.
-
Background InformationB7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.
-
HandlingCentrifuge the vial prior to opening.
-
UsageFor Research Use Only! Not to be used in humans
-
TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
-
Latin nameMus musculus
-
Additional sourceRecombinants or rec. proteins
-
Grouprecombinants
-
Gene target
-
Gene symbolVTCN1, H4C6, HHLA2, H4C13, RNY4P2, LRRC23, H4C8, PCDHGB7, NCR3LG1, CD274
-
Short nameB7-H4 /VTCN1, mouse recombinant
-
TechniqueRecombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
-
Hostmouse
-
SpeciesMouse, Mouses
-
Alternative nameB7-H4 /V-set domain containing T cellular activation inhibitor 1, mouse Rec.
-
Alternative techniquerec, murine
-
Alternative to gene targetV-set domain containing T cell activation inhibitor 1, VTCN1 and IDBG-101440 and ENSG00000134258 and 79679, protein binding, Cell surfaces, Vtcn1 and IDBG-179327 and ENSMUSG00000051076 and 242122, VTCN1 and IDBG-634392 and ENSBTAG00000014466 and 539919
-
Gene info
-
Identity
-
Gene
-
Long gene nameV-set domain containing T cell activation inhibitor 1
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2005-02-25
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- V-set domain containing
- B7 family
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameH4 clustered histone 6
-
Synonyms gene
-
Synonyms gene name
- H4 histone family, member C
- histone 1, H4f
- histone cluster 1, H4f
- histone cluster 1 H4 family member f
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1998-09-07
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- H4 histones
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameHERV-H LTR-associating 2
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1999-09-07
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- C1-set domain containing
- V-set domain containing
- B7 family
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameH4 clustered histone 13
-
Synonyms gene
-
Synonyms gene name
- H4 histone family, member K
- histone 1, H4l
- histone cluster 1, H4l
- histone cluster 1 H4 family member l
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1998-09-07
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- H4 histones
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameRNY4 pseudogene 2
-
Synonyms gene name
- RNA, Y4 small cytoplasmic (associated with Ro protein) pseudogene 2
- RNA, Ro-associated Y4 pseudogene 2
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1993-08-25
-
Entrez gene record
-
RefSeq identity
Gene info
-
Identity
-
Gene
-
Long gene nameleucine rich repeat containing 23
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2006-01-24
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameH4 clustered histone 8
-
Synonyms gene
-
Synonyms gene name
- H4 histone family, member H
- histone 1, H4h
- histone cluster 1, H4h
- histone cluster 1 H4 family member h
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1998-09-07
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- H4 histones
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameprotocadherin gamma subfamily B, 7
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2000-06-28
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Clustered protocadherins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namenatural killer cell cytotoxicity receptor 3 ligand 1
-
Synonyms
-
Synonyms name
-
Locus
-
Discovery year2012-04-12
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Receptor ligands
- C1-set domain containing
- B7 family
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameCD274 molecule
-
Synonyms gene
-
Synonyms gene name
- programmed cell death 1 ligand 1
- CD274 antigen
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2003-11-13
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Receptor ligands
- C2-set domain containing
- V-set domain containing
- B7 family
- CD molecules
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data