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Stock availabilitIn Stock
In Stock
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CAS number
22144-77-0
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Description
Actin polymerization inhibitor
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Molecular weight
507,63 g/mol
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Primary research fields
Cancer, Apoptosis
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Other name
(3S,3aR,4S,6S,6aR,7E,10S,12S,13E,15R,15aR)-3-Benzyl-6-hydroxy-4,10,12-trimethyl-5-methylene-1-oxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate, Zygosporin A
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C30H37NO6
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Origin
Synthetic
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Purity pourcentage
>98% (TLC); NMR (Conforms)
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Soluble in
Soluble to 10 mM in ethanol and to 50 mM in DMSO
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Physical appearance
White Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R62 - Possible risk of impaired fertility R68 - Possible risk of irreversible effects Hazard Phrases: H300-H361 Precautionary Phrases: P264-P281-P301 + P310
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PubChem number
5458428
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Scientific context
Cytochalasins have the ability to bind to actin filaments and block polymerization and elongation of actin. As a result, they can change cellular morphology, inhibit cellular processes and cause cells to undergo apoptosis (1). Cytochalasin D in particular can inhibit protein synthesis (2).
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Bibliography
1. Haidle A., and Myers A. (2004) Proc Natl Acad Sci. 101(33): 12048-12053. 2. Ornelles et al., (1986) Mol Cell Biol. 6(5): 1650-1662.
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Release date
16-May-2011
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PubMed number
27604950|27554054|25672508
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Tested applications
Cell treatment|In vitro inhibition|In vitro inhibition
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Tested reactivity
Human|Mycobacterium tuberculosis|Human
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Representative figure legend
Chemical structure of Cytochalasin D (SIH-241), a Disrupts actin filaments. CAS #: 22144-77-0. Molecular Formula: C30H37NO6. Molecular Weight: 507.63 g/mol. Chemical structure of Cytochalasin D, a Disrupts actin filaments (SIH-241). CAS # 22144-77-0. Molecular Formula: C30H37NO6.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
