CXCR1 Antibody

• Catalog number
  R31191
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  CXCR1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the CXCR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This CXCR1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P25024
• Purity
  Antigen affinity
• Description
  Chemokine CXC Motif Receptor 1, also known as IL8R, is the receptor for IL8. Morris et al.(1992) mapped the gene to chromosome 2q35. Hartl et al.(2007) concluded that CXCR1 cleavage and its functional consequences represent an important pathophysiologic mechanism in CF and other neutrophilic airway diseases. Binding of IL-8 to its receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. CXCR1 binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
• Immunogen
  An amino acid sequence from the N-terminus of human Chemokine CXC Motif Receptor 1 (DEDYSPCMLETETLN) was used as the immunogen for this CXCR1 antibody.
• Storage
  After reconstitution, the CXCR1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CXCR1  
• Gene symbol
  CXCR1
• Short name
  Anti-CXCR1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to CXCR1
• Alternative technique
  antibodies
• Alternative to gene target
  chemokine (C-X-C motif) receptor 1, C-C and C-C-CKR-1 and CD128 and CD181 and CDw128a and CKR-1 and CMKAR1 and IL8R1 and IL8RA and IL8RBA, CXCR1 and IDBG-80821 and ENSG00000163464 and 3577, interleukin-8 binding, Plasma membranes, Cxcr1 and IDBG-166431 and ENSMUSG00000048480 and 227288

Gene info

• Identity
  HGNC:6026
• Gene
  CXCR1
• Long gene name
  C-X-C motif chemokine receptor 1
• Synonyms gene
  • CMKAR1
  • IL8RA
• Synonyms gene name
  • interleukin 8 receptor, alpha
  • chemokine (C-X-C motif) receptor 1
• Synonyms
  • CKR-1
  • CDw128a
  • CD181
• GenBank acession
  • U11870
• Locus
  2q35
• Discovery year
  1992-11-09
• Entrez gene record
  3577
• Pubmed identfication
  • 1303245
  • 1427896
• RefSeq identity
  • NM_000634
• Classification
  • C-X-C motif chemokine receptors
  • CD molecules
  • Interleukin receptors
• VEGA ID
  OTTHUMG00000133108

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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