Curcubitacin E

Alternative_name

Cuc E; α-Elaterin; α-Elaterine; NSC106399; BRN2343323
Description

Curcubitacin E is a potent actin depolymerization inhibitor. Shown to have a different mechanism of action compared to Jasplakinolide (Cat. No. 1689), binding to a different site. Binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, stabilizing F-actin without affecting actin polymerization or nucleation. Does not bind to monomeric actin (G-actin). Acts as an immunomodulator with anti-inflammatory and anti-tumorigenic properties in a range of cancer cell lines, mediated by its action on the cellular cytoskeleton, on mitotic pathways as well as on cellular autophagy.
CAS Number

18444-66-1
Structure Available

Yes
Molecular Formula

C₃₂H₄₄O8₈
Molecular Weight

556.7
Cell Permeable

yes
Purity

≥98% by HPLC
Solubilities

DMSO (~15 mg/ml)
Handling

Protect from air and light
Tag Line

A potent actin depolymerization inhibitor
Storage Condition

-20°C
Shipping Condition

Gel Pack
Shelf Life

36 months
PubChem CID

5281319
PubChem CID Link
SMILES

CC(=O)OC(C)(C)C=CC(=O)C(C)(C1C(CC2(C1(CC(=O)C3(C2CC=C4C3C=C(C(=O)C4(C)C)O)C)C)C)O)O
InChi

InChI=1S/C32H44O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-14,19,21-22,25,34-35,39H,11,15-16H2,1-9H3/b13-12+/t19-,21-,22+,25+,29+,30-,31+,32+/m1/s1
InChi Key

NDYMQXYDSVBNLL-MUYMLXPFSA-N
Data Sheet Link
MSDS Available

Yes