CRTAP Antibody

• Catalog number
  bs-12949R
• Price
  Please ask
• Size
  0.1ml

• Long name
  CRTAP Primary Polyclonal Antibody
• Also known as
  CRTAP PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  CRTAP
• Specificity
  This is a highly specific antibody against CRTAP.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CRTAP
• Gene ID number
  10491
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  CRTAP is a secreted protein localizing to the extracellular space that plays a role in collagen post-translational modifications, extracellular fibril assembly and intracellular trafficking. CRTAP is widely expressed with predominant expression in articular chondrocytes. It contains a signal peptide and a tetratricopeptide-like helical domain and is essential for normal bone formation. In the endoplasmic reticulum (ER), CRTAP forms a complex with Gros1 and CyPB (cyclophilin B) and is required for the efficient 3-hydroxylation of target prolyl residues in Collagen Type I molecules, the major structural proteins of skin and bone. Mutations in the gene encoding CRTAP can lead to autosomal recessive osteogenesis imperfecta (OI) type 7 and type 2B. OI, also known as brittle bone disease, is characterized by bone fragility and susceptibility to fractures. OI type 7 is a mild form of this disorder, while OI type 2B is a neonatal lethal condition.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Cartilage associated protein; LEPREL3; leprecan-like 3; CASP; CRTAP_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CRTAP  
• Gene symbol
  CRTAP
• Short name
  Anti-CRTAP
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  CRTAP Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:2379
• Gene
  CRTAP
• Long gene name
  cartilage associated protein
• Synonyms
  • CASP
  • LEPREL3
  • P3H5
• Synonyms name
  • leprecan-like 3
  • prolyl 3-hydroxylase family member 5 (non-enzymatic)
• GenBank acession
  • AJ006470
• Locus
  3p22.3
• Discovery year
  1999-10-19
• Entrez gene record
  10491
• Pubmed identfication
  • 9217321
  • 10429950
• Classification
  • Prolyl 3-hydroxylase family
• VEGA ID
  OTTHUMG00000130746
• Locus Specific Databases
  • Osteogenesis Imperfecta Variant Database
  • LRG_4

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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