COL1A2 Antibody

• Catalog number
  F41539-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  COL1A2
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the COL1A2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This COL1A2 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P08123
• Purity
  Antigen affinity
• Description
  This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish].
• Immunogen
  A portion of amino acids 16-43 from the human protein was used as the immunogen for this COL1A2 antibody.
• Storage
  Aliquot the COL1A2 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  COL1A2  
• Gene symbol
  COL1A2, COL1A2-AS1
• Short name
  Anti-COL1A2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to COL1A2
• Alternative technique
  antibodies
• Alternative to gene target
  collagen, type I, alpha 2, OI4, COL1A2 and IDBG-27319 and ENSG00000164692 and 1278, protein binding, Extracellular, Col1a2 and IDBG-127903 and ENSMUSG00000029661 and 12843, COL1A2 and IDBG-629088 and ENSBTAG00000013472 and 282188

Gene info

• Identity
  HGNC:2198
• Gene
  COL1A2
• Long gene name
  collagen type I alpha 2 chain
• Synonyms gene
  • OI4
• Synonyms gene name
  • osteogenesis imperfecta type IV
  • collagen, type I, alpha 2
  • collagen type I alpha 2
• Synonyms name
  • alpha 2(I)-collagen
  • alpha-2 collagen type I
  • type I procollagen
  • collagen I, alpha-2 polypeptide
  • collagen of skin, tendon and bone, alpha-2 chain
• GenBank acession
  • Z74616
• Locus
  7q21.3
• Discovery year
  2001-06-22
• Entrez gene record
  1278
• Pubmed identfication
  • 3857213
  • 2897363
• RefSeq identity
  • NM_000089
• Classification
  • Collagens
• VEGA ID
  OTTHUMG00000148675
• Locus Specific Databases
  • Osteogenesis Imperfecta Variant Database
  • LRG_2

Gene info

• Identity
  HGNC:53133
• Gene
  COL1A2-AS1
• Long gene name
  COL1A2 antisense RNA 1
• Synonyms
  • TCONS_00013888
  • lncRNA8975-1
• Locus
  7q21.3
• Discovery year
  2017-03-03
• Entrez gene record
  101927525
• Pubmed identfication
  • 27866191
• Classification
  • Antisense RNAs

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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