ICOSLG /B7-H2 /CD275, mouse recombinant
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Catalog numberP1106-50
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PricePlease ask
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Size50 µg
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SynonymsB7-H2, ICOS Ligand, B7-like Protein Gl50, B7RP-1
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Alternative_namesB7-H2, ICOS Ligand, B7-like Protein Gl50, B7RP-1
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DescriptionLigand for the T-cell-specific cell surface receptor ICOS
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RecombinantYes
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SourceCHO cells
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Purity by SDS PAGE≥95%
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AssaySDS-PAGE
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Endotoxin Level< 0.06 EU/ug
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Activity Specifications test methodMeasured by its binding ability in a functional ELISA.
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Biological activityImmobilized human ICOS at 1ug/ml (100ul/well) can bind biotinylated B7-H2 (mouse), Fc (mouse) (rec.) (non-lytic) with a linear range of 0.1-1.0ug/ml.
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Binding CapacityImmobilized human ICOS at 1ug/ml (100ul/well) can bind biotinylated B7-H2 (mouse), Fc (mouse) (rec.) (non-lytic) with a linear range of 0.1-1.0ug/ml.
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Storage Temp-20°C
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ShippingGel pack
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Shelf Life12 months
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AppearanceLyophilized
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Physical form descriptionLyophilized from 0.2 um-filtered solution in PBS
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Reconstitution InstructionsReconstitute at 100 ug/ml in sterile PBS
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Background InformationMouse CD275 (B7-H2) is a member of the growing B7 family of immune costimulatory proteins. CD275 has been identified as the ligand for ICOS, a member of the CD28 family of co-stimulatory receptors. Mouse CD275 is expressed on resting B cells and at low levels on monocytes. The CD275/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolICOSLG, NCAPH2, TUBA3D, HHLA2, RNY4P2, LRRC23, NME2, PCDHGB7, CFB, NCR3LG1
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Short nameICOSLG /B7-H2 /CD275, mouse recombinant
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TechniqueRecombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Hostmouse
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SpeciesMouse, Mouses
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Alternative nameinducible T-cellular co-stimulator ligand /B7-H2 /CD275, mouse Rec.
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Alternative techniquerec, murine
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Alternative to gene targetinducible T-cell co-stimulator ligand, ICOSLG and IDBG-5107 and ENSG00000160223 and 102723996,23308, protein binding, Plasma membranes, Icosl and IDBG-168471 and ENSMUSG00000000732 and 50723, ICOSLG and IDBG-639662 and ENSBTAG00000014880 and 507857
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Gene info
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Identity
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Gene
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Long gene nameinducible T cell costimulator ligand
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Synonyms gene
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Synonyms gene name
- inducible T-cell costimulator ligand
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-12-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- B7 family
- CD molecules
- Receptor ligands
- C2-set domain containing
- V-set domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namenon-SMC condensin II complex subunit H2
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Synonyms gene name
- non-SMC condensin II complex, subunit H2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2006-09-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Condensin II subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nametubulin alpha 3d
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2007-02-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Tubulins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameHERV-H LTR-associating 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-09-07
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C1-set domain containing
- V-set domain containing
- B7 family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRNY4 pseudogene 2
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Synonyms gene name
- RNA, Y4 small cytoplasmic (associated with Ro protein) pseudogene 2
- RNA, Ro-associated Y4 pseudogene 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-08-25
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Entrez gene record
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RefSeq identity
Gene info
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Identity
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Gene
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Long gene nameleucine rich repeat containing 23
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Synonyms
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GenBank acession
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Locus
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Discovery year2006-01-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameNME/NM23 nucleoside diphosphate kinase 2
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Synonyms gene name
- non-metastatic cells 2, protein (NM23B) expressed in
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Synonyms
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GenBank acession
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Locus
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Discovery year1991-07-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- NME/NM23 family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameprotocadherin gamma subfamily B, 7
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-06-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Clustered protocadherins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecomplement factor B
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Synonyms gene
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Synonyms gene name
- B-factor, properdin
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Synonyms
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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RefSeq identity
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Classification
- Complement system activation components
- Sushi domain containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namenatural killer cell cytotoxicity receptor 3 ligand 1
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Synonyms
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Synonyms name
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Locus
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Discovery year2012-04-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Receptor ligands
- C1-set domain containing
- B7 family
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data