CDKN1B (Thr157) Antibody

• Catalog number
  bs-5228R
• Price
  Please ask
• Size
  0.1ml

• Long name
  CDKN1B (Thr157) Primary Polyclonal Antibody
• Also known as
  CDKN1B (Thr157) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  CDKN1B Thr157
• Specificity
  This is a highly specific antibody against CDKN1B Thr157.
• Modification s
  Phosphorylation
• Modification site s
  Thr157
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human CDKN1B around the phosphorylation site of Thr157 [PA(p-T)DD]
• Gene ID number
  1027
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Cell cycle progression is regulated by cyclins and their cognate Cdks. p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. p27 Kip1 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27 Kip 1; while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  p27Kip1Thr157; p-p27Kip1Thr157; p-p27Kip1T157; CDN1B_HUMAN; AA408329; AI843786; Cdki1b; CDKN 1B; CDKN 4; CDKN1B; CDKN1B; CDKN4; CDKN4; Cyclin Dependent Kinase Inhibitor 1B; Cyclin Dependent Kinase Inhibitor 1B; Cyclin dependent kinase inhibitor p27; Cyclin dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B p27, Kip1; Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor p27 Kip1; KIP 1; KIP1; MEN1B; MEN4; OTTHUMP00000195098; OTTHUMP00000195099; p27; p27 Kip1; P27-like cyclin-dependent kinase inhibitor; P27KIP1.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CDKN1B   Thr157  
• Gene symbol
  CDKN1B
• Short name
  Anti-CDKN1B Thr157
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  CDKN1B (Thr157) Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  cyclin-dependent kinase inhibitor 1B (p27, Kip1), CDKN4 and KIP1 and MEN1B and MEN4 and P27KIP1, CDKN1B and IDBG-20317 and ENSG00000111276 and 1027, transforming growth factor beta receptor, nuclei, Cdkn1b and IDBG-194318 and ENSMUSG00000003031 and 12576, CDKN1B and IDBG-639416 and ENSBTAG00000018254 and 512613

Gene info

• Identity
  HGNC:1785
• Gene
  CDKN1B
• Long gene name
  cyclin dependent kinase inhibitor 1B
• Synonyms gene name
  • cyclin-dependent kinase inhibitor 1B (p27, Kip1)
• Synonyms
  • KIP1
  • P27KIP1
• GenBank acession
  • AF480891
• Locus
  12p13.1
• Discovery year
  1995-09-14
• Entrez gene record
  1027
• Pubmed identfication
  • 8033212
• RefSeq identity
  • NM_004064
• VEGA ID
  OTTHUMG00000149914

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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