CD437 for cell activation

CD437 for cell activation is available 2 times from Biovision labs

2636-25 | CD437 for cell activationsize: 25 mg | 686.2 USD

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2636-5 | CD437 for cell activationsize: 5 mg | 229.9 USD

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  • Description
    CD437 is the adamantyl arotinoid of the retinoid-related molecule family that acts as a selective agonist of retinoic acid receptor (RAR)γ (Kds = 6.5 μM, 2.5 μM, and 77 nM for RARα, β, and γ, respectively). CD437 is cytotoxic to the acute myeloid leukemia cell line NB4 (EC₅₀ = 0.17 μM), inducing DNA damage by producing DNA double strand breaks. CD437 also induces cell cycle arrest and apoptosis in various other cancer cells including melanoma, breast, non-small lung, and prostate cancer cells through RAR-dependent and -independent signaling pathways. Treatment of mouse embryonic fibroblasts (MEFs) with CD437 early in the reprogramming process significantly increases reprogramming efficiency up to 20-fold.
  • Peptide sequence
    N/A
  • CAS number
    125316-60-1
  • Molecular weight
    398.49
  • Category
    Biochemicals
  • Other name
    6-​(4-​hydroxy-​3-​tricyclo[3.3.1.13,​7]dec-​1-​ylphenyl)-​2-​naphthalenecarboxylic acid; AHPN
  • Molecular formula
    C₂₇H₂₆O₃
  • Physical appearance
    White solid
  • Supplied with
    N/A
  • Is this a salt?
    No
  • Is it cell-permeable?
    Yes
  • Purification
    >95%
  • Reconstitute instructions
    DMSO (>10 mg/ml)
  • Storage condition
    -20 ̊C
  • Shipping condition
    Gel pack
  • Maximum time for storage
    36 months
  • Storage instructions
    Protect from air and light
  • Additional description
    For cells, cell lines and tissues in culture till half confluency.
  • Gene target
  • Short name
    CD437 for activation
  • Technique
    activation
  • Alternative name
    CD437 to measure cellular activation
  • Tissue
    cell
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