Caspase10 Antibody
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Catalog numberPA1513
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PricePlease ask
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Size0,1 mg
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Target antigenCaspase10
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ClonalityPolyclonal antibody
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ClonePolyclonal antibody
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Raised inrabbit
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Type of the antibodyIgG polyclonal antibody
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Product formfreeze-dried
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Reacts with specieshuman, rat Predicted to work with: mouse
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AnalysesWB,IHC-P
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ImmunogenA synthetic peptide corresponding to a sequence at the N-terminus of human CASP10(220-236aa VKTFLEALPRAAVYRMN).
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Product configurationEach vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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PurificationImmunogen affinity purified.
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SolubilizationThe powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtionsKeep the Caspase10 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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TipsThe Caspase10 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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BackgroundCaspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene. The Caspase 10 gene contains 11 exons and spans about 48 kb. This gene is mapped to 2q33.1. It is transcribed in the centromere-to-telomere direction.This gene encodes a protein that is a member of the cysteine-aspartic acid protease(caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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Related articles1. Lee, H.-J., Pyo, J.-O., Oh, Y., Kim, H.-J., Hong, S., Jeon, Y.-J., Kim, H., Cho, D.-H., Woo, H.-N., Song, S., Nam, J.-H., Kim, H. J., Kim, K.-S., Jung, Y.-K.AK2 activates a novel apoptotic pathway through formation of a complex with FADD and caspase-10.Nature Cell Biol. 9: 1303-1310, 2007. 2. Park, W. S., Lee, J. H., Shin, M. S., Park, J. Y., Kim, H. S., Lee, J. H., Kim, Y. S., Lee, S. N., Xiao, W., Park, C. H., Lee, S. H., Yoo, N. J., Lee, J. Y.Inactivating mutations of the caspase-10 gene in gastric cancer.Oncogene 21: 2919-2925, 2002. 3. Wang, J., Zheng, L., Lobito, A., Chan, F. K., Dale, J., Sneller, M., Yao, X., Puck, J. M., Straus, S. E., Lenardo, M. J.Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.Cell 98: 47-58, 1999.
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Gene NameCASP10
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Protein NameCaspase-10(CASP-10)
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Gene Full Namecaspase 10, apoptosis-related cysteine peptidase
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SynonymsALPS 2 antibody|ALPS2 antibody|Apoptosis related cysteine peptidase antibody|Apoptotic protease Mch 4 antibody|Apoptotic protease Mch-4 antibody|CASP 10 antibody|CASP-10 antibody|CASP10 antibody|CASP10 protein antibody|CASPA_HUMAN antibody|Caspase 10 apoptosis related cysteine peptidase antibody|Caspase 10 apoptosis related cysteine protease antibody|Caspase-10 subunit p12 antibody|Caspase10 antibody|FADD Like Ice 2 antibody|FADD like ICE2 antibody|Fas Associated Death Domain Protein antibody|FAS associated death domain protein interleukin 1B converting enzyme 2 antibody|FAS-associated death domain protein interleukin-1B-converting enzyme 2 antibody|FLICE 2 antibody|FLICE2 antibody|ICE Like Apoptotic Protease 4 antibody|ICE-like apoptotic protease 4 antibody|Interleukin 1B Converting Enzyme 2 antibody|MCH 4 antibody|MCH4 antibody
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Uniprot IDQ92851
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PropertiesIf you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Short nameCaspase10 Antibody
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TechniqueAntibody, antibodies against human proteins, antibodies for
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Alternative nameCaspase10 (antibody to-)
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Alternative techniqueantibodies
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MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data