Alpha/Beta-Synuclein Antibody
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Catalog number
bs-50564R
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Price
Please ask
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Size
0.1ml
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Long name
Alpha/Beta-Synuclein Primary Polyclonal Antibody
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Also known as
Alpha/Beta-Synuclein PAb
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Category
Primary Antibodies
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Conjugation
Unconjugated
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Target Antigen
Alpha/Beta-Synuclein
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Specificity
This is a highly specific antibody against Alpha/Beta-Synuclein.
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Modification s
None
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Modification site s
Unmodified antibody
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Clonality
Polyclonal antibody
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Clone number
Polyclonal antibody
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Concentration
1ug per 1ul
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Source
Recombinant human protein purified from E.coli (His-alpha-synuclein)
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Swiss Prot
O43524,Q16143
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Tested Applications
WB, IP
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Recommended dilutions
WB (0.5 ug/ml), IP (2.0ug)
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Cross reactivity
Human, Mouse, Rat
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Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigen
Synucleins are a family of soluble proteins common to vertebrates, primarily expressed in neural tissue and in certain tumors.[1] The synuclein family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. Interest in the synuclein family began when alpha-synuclein was found to be mutated in several families with autosomal dominant Parkinson's disease. [2] All synucleins have in common a highly conserved alpha-helical lipid-binding motif with similarity to the class-A2 lipid-binding domains of the exchangeable apolipoproteins. Synuclein family members are not found outside vertebrates, although they have some conserved structural similarity with plant 'late-embryo-abundant' proteins. [1] Normal cellular functions have not been determined for any of the synuclein proteins. Some data suggest a role in the regulation of membrane stability and/or turnover. Mutations in alpha-synuclein are associated with early-onset familial Parkinson's disease and the protein aggregates abnormally in Parkinson's disease, Alzheimer's disease, Lewy body disease, and other neurodegenerative diseases. [3] [4] The gamma-synuclein protein's expression in breast tumors is a marker for tumor progression. [5] [6]
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Purification method
This antibody was purified via Protein A.
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Storage conditions
Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Description
The Anti-Alpha/Beta-Synuclein is a α- or alpha protein sometimes glycoprotein present in blood.
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Properties
If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Short name
Anti-Alpha/Beta-Synuclein
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Technique
Antibody, antibodies against human proteins, antibodies for
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Host
Rabbit (Oryctolagus cuniculus)
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Isotype
Immunoglobulin G (IgG)
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Alternative name
Alpha/Beta-Synuclein Polyclonal Antibody
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Alternative technique
antibodies
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MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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