Azidothymidine
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Catalog numberB1113-50
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PricePlease ask
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Size50 mg
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Alternative_name3'-Azido-3'-deoxythymidine; AZT; Zidovudine
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DescriptionAzidothymidine is a nucleoside reverse transcriptase inhibitor that, following triphosphorylation by thymidine kinase, potently blocks replication of HIV (EC₅₀ = 3 nM) with low cytotoxicity (CC₅₀ > 5 μM). Displays 100-fold selectivity for HIV reverse transcriptase over DNA polymerase α. Suppresses HIV-1 replication and enhances cell viability in HIV-1 infected T cells. Antiretroviral agent. Also decreases CRISPR-mediated homology directed repair (HDR) efficiency.
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CAS Number30516-87-1
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₀H₁₃N₅O₄
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Molecular Weight267.24
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>25 mg/ml) or H2O (>10 mg/ml)
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HandlingProtect from air and moisture
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Tag LineA nucleoside reverse transcriptase inhibitor and homology directed repair (HDR) blocker
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberMFCD00006536
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PubChem CID35370
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SMILESCC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-]
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InChiInChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
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InChi KeyHBOMLICNUCNMMY-XLPZGREQSA-N
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MSDS AvailableYes
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Gene target
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Short nameAzidothymidine
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Alternative nameAzidothymidine
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