Aurora Kinase B Inhibitor (AZD1152-HQPA)
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Catalog number
1583-5
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Price
Please ask
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Size
5 mg
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Alternative_name
AZD1152-HQPA
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Description
A potent and specific Aurora kinase B inhibitor. It is 1000-fold more selective for aurora kinase B than for aurora kinase A ( Ki values of 1300 nM and 0.36 nM for aurora kinase A and B, respectively). At concentrations as low as 0.01 µM, AZD 1152 produced a significant (p
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CAS Number
722544-51-6
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₆H₃₀FN₇O₃
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Molecular Weight
507.56
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Cell Permeable
Yes
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Purity
≥99% by HPLC
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Solubilities
DMSO
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Handling
Protect from light and moisture
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Tag Line
An Aurora kinase B inhibitor
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Storage Condition
-20°C
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Shipping Condition
RT
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Shelf Life
24months
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MDL Number
MFCD10687152
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PubChem CID
16007391
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SMILES
CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO
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InChi
InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28- 17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3, 5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)
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InChi Key
QYZOGCMHVIGURT-UHFFFAOYSA-N
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MSDS Available
Yes
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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