PI3-K? Inhibitor, AS-605240

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Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

PI3-K? Inhibitor AS-605240
Gene symbol

PIK3C2B, PIK3CA, PIK3C2A, H4C13, PIK3R5, TUBA1B, KRT7-AS, DM1-AS, RAP2A
Short name

PI3-K? Inhibitor, AS-605240
Alternative name

PI3-K? suppressor, AS-605240

Identity

HGNC:8972
Gene

PIK3C2B
Long gene name

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Synonyms gene name
- phosphoinositide-3-kinase, class 2, beta polypeptide
- phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Synonyms
- C2-PI3K
- PI3K-C2beta
GenBank acession
- Y11312
Locus

1q32.1
Discovery year

1998-05-21
Entrez gene record

5287
Pubmed identfication
- 9144573
- 9830063
RefSeq identity
- NM_002646
Classification
- Phosphatidylinositol 3-kinase subunits
VEGA ID

OTTHUMG00000036101

Identity

HGNC:8975
Gene

PIK3CA
Long gene name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Synonyms gene name
- phosphoinositide-3-kinase, catalytic, alpha polypeptide
- phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Synonyms
- PI3K
Locus

3q26.32
Discovery year

1994-07-15
Entrez gene record

5290
Pubmed identfication
- 1322797
Classification
- Phosphatidylinositol 3-kinase subunits
VEGA ID

OTTHUMG00000157311
Locus Specific Databases
- LRG_310

Identity

HGNC:8971
Gene

PIK3C2A
Long gene name

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms gene name
- phosphoinositide-3-kinase, class 2, alpha polypeptide
- phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Synonyms
- PI3K-C2alpha
GenBank acession
- Y13367
Locus

11p15.1
Discovery year

1998-05-21
Entrez gene record

5286
Pubmed identfication
- 9337861
RefSeq identity
- NM_002645
Classification
- Phosphatidylinositol 3-kinase subunits
VEGA ID

OTTHUMG00000166036

Identity

HGNC:4791
Gene

H4C13
Long gene name

H4 clustered histone 13
Synonyms gene
- H4FK
- HIST1H4L
Synonyms gene name
- H4 histone family, member K
- histone 1, H4l
- histone cluster 1, H4l
- histone cluster 1 H4 family member l
Synonyms
- H4.k
- H4/k
GenBank acession
- X83548
Locus

6p22.1
Discovery year

1998-09-07
Entrez gene record

8368
Pubmed identfication
- 9031620
- 9439656
- 12408966
RefSeq identity
- NM_003546
Classification
- H4 histones
VEGA ID

OTTHUMG00000016211