anti-TPM1 Antibody

• Catalog number
  29-560
• Price
  Please ask
• Size
  100 ug

• Gene info
  TPM1 is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction.This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.
• Gene names
  TPM1, CMH3, TMSA, TPM1-alpha, CMD1Y, LVNC9, C15orf13, HTM-alpha
• Antibodie s label
  unlabelled serum
• Purity
  Antibody is purified by protein A chromatography method.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Antigen
  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TPM1.
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry
• Antibody advice
  TPM1 antibody can be used for detection of TPM1 by ELISA at 1:312500. TPM1 antibody can be used for detection of TPM1 by western blot at 1.25 ug/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
• Suspention pH azide
  Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.
• Keep at
  For short periods of storage (days) store at 4 grades C. For longer periods of storage, store TPM1 antibody at -20 grades C. As with any antibody avoid repeat freeze-thaw cycles.
• Works with
  Human, Mouse, Rat, Dog, Zebrafish
• Omim nr
  27597085
• Ncbi nr
  NP_000357
• KDa
  31 kDa, 33 kDa, 33 kDa, 33 kDa
• Vial with antibody
  Lyophilized
• Quantity per ml
  1 mg/ml
• NCBI GENE nr
  7168
• GENE symbol
  TPM1
• Antigene name
  tropomyosin 1 (alpha)
• Source
  Homo sapiens
• Protein nr
  P09493
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TPM1  
• Gene symbol
  TPM1-AS, TPM1
• Short name
  anti-TPM1 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toTPM1 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  tropomyosin 1 (alpha), C15orf13 and CMD1Y and CMH3 and HTM-alpha and LVNC9 and TMSA, TPM1 and IDBG-15400 and ENSG00000140416 and 7168, structural constituent of muscle, Cytoplasm, Tpm1 and IDBG-180208 and ENSMUSG00000032366 and 22003, TPM1 and IDBG-646543 and ENSBTAG00000005373 and 281544

Gene info

• Identity
  HGNC:53635
• Gene
  TPM1-AS
• Long gene name
  TPM1 antisense RNA
• Synonyms
  • TPM1-AS1
• Synonyms name
  • TPM1 antisense RNA 1
• Locus
  15q22.2
• Discovery year
  2017-08-09
• Entrez gene record
  111064646
• Pubmed identfication
  • 28754317
• RefSeq identity
  • NR_147233
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:12010
• Gene
  TPM1
• Long gene name
  tropomyosin 1
• Synonyms gene
  • C15orf13
  • CMH3
• Synonyms gene name
  • chromosome 15 open reading frame 13
  • cardiomyopathy, hypertrophic 3
  • tropomyosin 1 (alpha)
• GenBank acession
  • AB209041
• Locus
  15q22.2
• Discovery year
  1991-07-18
• Entrez gene record
  7168
• Pubmed identfication
  • 10343096
  • 8205619
  • 25369766
• RefSeq identity
  • NM_001018004
• Classification
  • Tropomyosins
• VEGA ID
  OTTHUMG00000132803
• Locus Specific Databases
  • FHC Mutation Database
  • LRG_387

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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