anti-TMP21 Antibody
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Catalog number3999
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PricePlease ask
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Size0.02 mg, 0.1 mg
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Gene infoTMP21 Antibody: TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity but not epsilon-secretase activity, and increased Abeta; production, demonstrating that TMP21 can modulate gamma-secretase activity.
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Gene namesTMP21 Antibody: p23, TMP21, S31I125, Tmp-21-I, S31III125, P24(DELTA), Transmembrane emp24 domain-containing protein 10, 21 kDa transmembrane-trafficking protein
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Antibodie s labelunlabelled serum
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PurityTMP21 Antibody is affinity chromatography purified via peptide column.
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Ab raised inRabbit
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TypePolyclonal
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ImmunoglobulinIgG
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AntigenTMP21 antibody was made against a 18 amino acid synthetic peptide from near the center of human TMP21.
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Immuno applicationELISA, Western Blot, immuno-histo-chemistry
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Antibody adviceTMP21 antibody can be used for detection of TMP21 by Western blot at 0.5 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 5 ug/mL.
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Suspention pH azideTMP21 Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep atTMP21 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works withHuman, Mouse, Rat
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Omim nr4885697
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Ncbi nrAAD31941
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Vial with antibodyin solution
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Quantity per ml1 mg/mL
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NCBI GENE nr10972
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GENE symbolTMED10
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Antigene nametransmembrane emp24-like trafficking protein 10 (yeast)
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SourceHomo sapiens
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Protein nrP49755
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolTMED10P1, TMED10
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Short nameanti-TMP21 Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toTMP21 (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nametransmembrane p24 trafficking protein 10 pseudogene 1
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Synonyms gene
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Synonyms gene name
- transmembrane emp24-like trafficking protein 10 (yeast) pseudogene
- transmembrane emp24-like trafficking protein 10 (yeast) pseudogene 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2005-08-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nametransmembrane p24 trafficking protein 10
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Synonyms gene name
- transmembrane emp24-like trafficking protein 10 (yeast)
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Synonyms
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GenBank acession
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Locus
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Discovery year2005-08-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Transmembrane p24 trafficking proteins
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data