Runx2 Antibody

• Catalog number
  6773-100
• Price
  Please ask
• Size
  100 μl

• Antibody Target
  Runx2
• Target Alternative Name
  RUNX2; AML3; CBFA1; OSF2; PEBP2A; Runt-related transcription factor 2; Acute myeloid leukemia 3 protein; Core-binding factor subunit alpha-1; Oncogene AML-3; Osteoblast-specific transcription factor 2; Polyomavirus enhancer-binding protein 2 alpha A subunit; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit
• Antibody Type
  Polyclonal
• Species Reactivities
  Human.
• Immunogen Sequence
  This RUNX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-474 amino acids surrounding S533 of human RUNX2.
• Accession
  860
• Gene Id
  Q13950
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  In PBS with 0.09% (W/V) sodium azide.
• Purification
  This antibody is purified through a protein A column, followed by peptide affinity purification.
• Application
  Western blot, IHC, FACS.
• Positive Control
  Western blot: CEM cell lysate, IHC: human tonsil tissue, FACS: NCI-H460 cells.
• Application And Usages
  Western blot: ~1:1000, IHC: 1:10 – 1:50, FACS: 1:10 – 1:50.
• Description
  The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1 (also designated AML-1, PEBP2åB, CBFA2), RUNX2 (also designated AML-3, PEBP2åA, CBFA1, Osf2) and RUNX3 (also designated AML-2, PEBPåC, CBFA3). RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX2 is essential for skeletal mineralization in that it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy and contributes to endothelial cell migration and vascular invasion of developing bones. Regulating RUNX2 expression may be a useful therapeutic tool for promoting bone formation. Mutations in the C-terminus of RUNX2 are associated with cleidocranial dysplasia syndrome, an autosomal-dominant skeletal dysplasia syndrome that is characterized by widely patent calvarial sutures, clavicular hypoplasia, supernumerary teeth, and short stature.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Runx2  
• Gene symbol
  RUNX2-AS1, RUNX2
• Short name
  Runx2 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Runx2 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:53512
• Gene
  RUNX2-AS1
• Long gene name
  RUNX2 antisense RNA 1
• Locus
  6p21.1
• Discovery year
  2017-05-12
• Entrez gene record
  105375077
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:10472
• Gene
  RUNX2
• Long gene name
  RUNX family transcription factor 2
• Synonyms gene
  • CCD
  • CBFA1
  • CCD1
• Synonyms gene name
  • runt-related transcription factor 2
  • runt related transcription factor 2
• Synonyms
  • AML3
  • PEBP2A1
  • PEBP2aA1
• GenBank acession
  • AF001450
• Locus
  6p21.1
• Discovery year
  1994-11-02
• Entrez gene record
  860
• Pubmed identfication
  • 7835892
• RefSeq identity
  • NM_004348
• Classification
  • Runt-related transcription factors
• VEGA ID
  OTTHUMG00000014774

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products