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Gene info
Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The retinoid X receptors (RXRs) family (RXRalpha, beta and gamma), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
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Gene names
RAR, NR1B1, Nuclear receptor subfamily 1 group B member 1, RAR-alpha
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Antibodie s label
unlabelled serum
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Purity
Protein G purified
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Ab raised in
Mouse
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Type
Monoclonal
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Monoclonal
763
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Immunoglobulin
IgG1
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Antigen
Peptide corresponding to amino acid residues from the N-terminal region of human retinoic acid receptor, a-isotype.
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Immuno application
Western Blot
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Antibody advice
The antibody has been directly tested for reactivity in Western blots in human tissues. It is anticipated that the antibody will also work with bovine, canine and mouse tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
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Suspention pH azide
100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
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Keep at
Retinoic Acid Receptor antibody can be stored at -20 grades C and is stable at -20 grades C for at least 1 year.
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Works with
Human, Mouse, Dog, Bovine
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Omim nr
133483
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Ncbi nr
P10276
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KDa
48
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Vial with antibody
in solution
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NCBI GENE nr
5914
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GENE symbol
RARA
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Antigene name
retinoic acid receptor, alpha
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Source
Homo sapiens
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Protein nr
P10276
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps